68076-36-8

68076-36-8 structure

Name: NH2-C4-NH-Boc
Chemical Name: tert-Butyl N-(4-aminobutyl)carbamate
CAS Number: 68076-36-8
Molecular Formula: C₉H₂₀N₂O₂
Molecular Weight: 188.267
Catalog: Organic raw materials Amino compound Acyclic monoamines, polyamines and their derivatives and salts
Create Date: 2018-07-13 14:20:15
Modify Date: 2025-08-21 17:27:06
NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Name	tert-Butyl N-(4-aminobutyl)carbamate
Synonyms	2-Methyl-2-propanyl (4-aminobutyl)carbamate BOC-NH(CH2)4NH2 HCL tert-butyl 4-aminobutylcarbamate Carbamic acid, N-(4-aminobutyl)-, 1,1-dimethylethyl ester (4-amino-butyl)-carbamic acid tert-butyl ester N-(1,1-dimethylethoxycarbonyl)-1,4-butanediamine BOC-DIAMINOBUTANE HCL N-Boc-1,4-butanediamine N-Boc-1,4-butandiamine N-T-BOC-BUTANDIAMINE HCL (4-aminobutyl)carbamic acid 1,1-dimethylethyl ester BUTTPARK 121 6-09 RARECHEM AR PA 0023 tert-ButylN-(4-aminobutyl)carbamate 4-(t-butoxycarbonylamino)butylamine N-BOC-1,4-DIAMINOBUTANE AURORA KA-4397 N-(tert-butoxycarbonyl)-1,4-diamino-butane BOC-DAB HCL N-tert-Butoxycarbonyl-1,4-butanediamine MFCD02090802 tert-butyl 4-amino butylcarbamate

Description	NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl/ether
References	[1]. Jiang F, et al.Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies.Bioorg Med Chem. 2020 Jan 1;28(1):115181.

Symbol	GHS05
Signal Word	Danger
Hazard Statements	H314
Precautionary Statements	P280-P305 + P351 + P338-P310
Personal Protective Equipment	Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	C
Risk Phrases	R34
Safety Phrases	S26-S36/37/39-S45
RIDADR	UN 2735 8/PG 3
WGK Germany	3
Hazard Class	8.0
HS Code	2924199090

HS Code	2924199090
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%