Methyl azetidine-3-carboxylate hydrochloride

Modify Date: 2024-01-02 09:13:41

Methyl azetidine-3-carboxylate hydrochloride Structure
Methyl azetidine-3-carboxylate hydrochloride structure
Common Name Methyl azetidine-3-carboxylate hydrochloride
CAS Number 100202-39-9 Molecular Weight 151.591
Density N/A Boiling Point 190.9ºC at 760 mmHg
Molecular Formula C5H10ClNO2 Melting Point 93.0 to 97.0 °C
MSDS USA Flash Point 69.3ºC

 Use of Methyl azetidine-3-carboxylate hydrochloride


Methyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs<

 Names

Name Methyl azetidine-3-carboxylate hydrochloride
Synonym More Synonyms

  Biological Activity

Description Methyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs<
Related Catalog
Target

Non-cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

 Chemical & Physical Properties

Boiling Point 190.9ºC at 760 mmHg
Melting Point 93.0 to 97.0 °C
Molecular Formula C5H10ClNO2
Molecular Weight 151.591
Flash Point 69.3ºC
Exact Mass 151.040009
PSA 38.33000
LogP 0.50960

 Safety Information

Hazard Codes Xi
Risk Phrases 36
Safety Phrases 26
HS Code 2933990090

 Synthetic Route

~99%

Methyl azetidine-3-carboxylate hydrochloride Structure

Methyl azetidin...

CAS#:100202-39-9

Literature: Eisai RandD Management Co., Ltd. Patent: EP1889836 A1, 2008 ; Location in patent: Page/Page column 80 ;

~99%

Methyl azetidine-3-carboxylate hydrochloride Structure

Methyl azetidin...

CAS#:100202-39-9

Literature: PFIZER INC.; BROWN, Matthew, Frank; MITTON-FRY, Mark. J.; HAN, Seungil; LALL, Manjinder; PLUMMER, Mark, Stephen; RISLEY, Hud, Lawrence; SHANMUGASUNDARAM, Veerabahu; STARR, Jeremy, T. Patent: WO2012/73138 A1, 2012 ; Location in patent: Page/Page column 55-56 ; WO 2012/073138 A1

~99%

Methyl azetidine-3-carboxylate hydrochloride Structure

Methyl azetidin...

CAS#:100202-39-9

Literature: Pfizer Products Inc. Patent: EP978279 A1, 2000 ;

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Azetidine-3-carboxylic Acid Methyl Ester Hydrochloride
3-Azetidinecarboxylic acid, methyl ester, hydrochloride (1:1)
Methyl 3-azetidinecarboxylate hydrochloride (1:1)
Methyl Azetidine-3-carboxylate Hydrochloride
Methyl 3-azetidinecarboxylate hydrochloride
Methyl azetidine-3-carboxylate hydrochloride (1:1)
methyl azetidine-3-carboxylate,hydrochloride
methylazetidine-3-carboxylatehydrochloride
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