Methyl 1-Cbz-azetidine-3-carboxylate

Modify Date: 2025-08-22 18:24:52

Methyl 1-Cbz-azetidine-3-carboxylate structure	Common Name	Methyl 1-Cbz-azetidine-3-carboxylate
	CAS Number	757239-60-4	Molecular Weight	249.262
	Density	1.3±0.1 g/cm3	Boiling Point	414.9±45.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₁₅NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	204.7±28.7 °C

Use of Methyl 1-Cbz-azetidine-3-carboxylate

Methyl 1-Cbz-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Cbz-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1

Name	1-O-benzyl 3-O-methyl azetidine-1,3-dicarboxylate
Synonym	More Synonyms

Description	Methyl 1-Cbz-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Cbz-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Density	1.3±0.1 g/cm3
Boiling Point	414.9±45.0 °C at 760 mmHg
Molecular Formula	C₁₃H₁₅NO₄
Molecular Weight	249.262
Flash Point	204.7±28.7 °C
Exact Mass	249.100113
PSA	55.84000
LogP	1.42
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.580

HS Code	2933990090

diazomethane

CAS#:186581-53-3

1-benzyloxycarb...

CAS#:97628-92-7

~10%

Methyl 1-Cbz-az...

CAS#:757239-60-4

Literature: Zhu, Gui-Dong; Gong, Jianchun; Gandhi, Virajkumar B.; Penning, Thomas D.; Giranda, Vincent L. Patent: US2006/229289 A1, 2006 ; Location in patent: Page/Page column 19 ;

Methyl azetidin...

CAS#:100202-39-9

Benzyl chloroformate

CAS#:501-53-1

Methyl 1-Cbz-az...

CAS#:757239-60-4

Literature: US2011/183960 A1, ; Page/Page column 27 ;

1-benzyloxycarb...

CAS#:97628-92-7

(Trimethylsilyl...

CAS#:18107-18-1

~98%

Methyl 1-Cbz-az...

CAS#:757239-60-4

Literature: MERCK SHARP and DOHME LIMITED Patent: WO2004/78750 A1, 2004 ; Location in patent: Page 81 ; WO 2004/078750 A1

Precursor 5
CAS#:97628-92-7 1-benzyloxycarb... CAS#:18107-18-1 (Trimethylsilyl... CAS#:186581-53-3 diazomethane CAS#:100202-39-9 Methyl azetidin...
CAS#:501-53-1 Benzyl chloroformate
DownStream 2
CAS#:97628-92-7 1-benzyloxycarb... CAS#:912444-78-1 Methyl 1-Cbz-3-...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1-CBZ-AZETIDINE-3-CARBOXYLIC ACID METHYL ESTER

1-[(Benzyloxy)carbonyl]-3-methyl-3-azetidinecarboxylic acid

1-Cbz-3-azetidinecarboxylic acid methyl ester

1-Benzyl 3-methyl 1,3-azetidinedicarboxylate

Methyl1-Cbz-azetidine-3-carboxylate

1-BENZYL 3-METHYL AZETIDINE-1,3-DICARBOXYLATE

HT799

Azetidine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester

1,3-Azetidinedicarboxylic acid, 3-methyl-, 1-(phenylmethyl) ester

methyl 1-benzyloxycarbonyl-3-azetidinecarboxylate

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China
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Methyl 1-Cbz-azetidine-3-carboxylate

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