1-BOC-AZETIDINE-3-CARBOXYLICACIDMETHYLESTER

Modify Date: 2025-08-21 17:45:31

1-BOC-AZETIDINE-3-CARBOXYLICACIDMETHYLESTER structure	Common Name	1-BOC-AZETIDINE-3-CARBOXYLICACIDMETHYLESTER
	CAS Number	610791-05-4	Molecular Weight	215.246
	Density	1.2±0.1 g/cm3	Boiling Point	269.0±33.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₇NO₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	116.5±25.4 °C
	Symbol	GHS07	Signal Word	Warning

Use of 1-BOC-AZETIDINE-3-CARBOXYLICACIDMETHYLESTER

Methyl 1-Boc-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Boc-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1

Name	Methyl 1-Boc-azetidine-3-carboxylate
Synonym	More Synonyms

Description	Methyl 1-Boc-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Boc-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Density	1.2±0.1 g/cm3
Boiling Point	269.0±33.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₇NO₄
Molecular Weight	215.246
Flash Point	116.5±25.4 °C
Exact Mass	215.115753
PSA	55.84000
LogP	0.73
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.481

MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
HS Code	2933990090

Methanol

CAS#:67-56-1

1-Boc-azetidine...

CAS#:142253-55-2

~99%

1-BOC-AZETIDINE...

CAS#:610791-05-4

Literature: PFIZER INC. Patent: WO2006/21881 A2, 2006 ; Location in patent: Page/Page column 61 ; WO 2006/021881 A2

1-Boc-azetidine...

CAS#:142253-55-2

(Trimethylsilyl...

CAS#:18107-18-1

~98%

1-BOC-AZETIDINE...

CAS#:610791-05-4

Literature: AGOURON PHARMACEUTICALS, INC. Patent: US2006/46991 A1, 2006 ; Location in patent: Page/Page column 55-56 ; US 20060046991 A1

Methyl azetidin...

CAS#:100202-39-9

Di-tert-butyl d...

CAS#:24424-99-5

~14%

1-BOC-AZETIDINE...

CAS#:610791-05-4

Literature: Eisai RandD Management Co., Ltd. Patent: US2008/214815 A1, 2008 ; Location in patent: Page/Page column 15 ;

Precursor 5
CAS#:67-56-1 Methanol CAS#:142253-55-2 1-Boc-azetidine... CAS#:18107-18-1 (Trimethylsilyl... CAS#:100202-39-9 Methyl azetidin...
CAS#:24424-99-5 Di-tert-butyl d...
DownStream 4
CAS#:142253-56-3 1-Boc-azetidine... CAS#:1340481-90-4 tert-Butyl 8-hy... CAS#:1340481-89-1 2-Methyl-2-prop... CAS#:1257293-79-0 tert-butyl 3-(2...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1-O-tert-butyl 3-O-methyl azetidine-1,3-dicarboxylate

1-BOC-AZETIDINE-3-CARBOXYLICACIDMETHYLESTER

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Tert-butylmethylazetidine-1,3-dicarboxylate
Price: Check
Purity: 95.0%
Delivery: 10 Day
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Chengdu Pukang Biotechnology Co., Ltd.
China
Product Name: 1-BOC-AZETIDINE-3-CARBOXYLICACIDMETHYLESTER
Price: ￥Inquiry/100kg
Purity: 98.0%
Delivery: 90 Day
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DC Chemicals Limited
China
Product Name: Methyl 1-Boc-azetidine-3-carboxylate
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: ￥58/1g

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1-BOC-AZETIDINE-3-CARBOXYLICACIDMETHYLESTER

Use of 1-BOC-AZETIDINE-3-CARBOXYLICACIDMETHYLESTER

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