142253-56-3

142253-56-3 structure

Name: 1-Boc-azetidine-3-yl-methanol
Chemical Name: 1-Boc-3-azetidinemethanol
CAS Number: 142253-56-3
Molecular Formula: C₉H₁₇NO₃
Molecular Weight: 187.236
Catalog: Chemical reagent Organic reagent Imine, hydrazine
Create Date: 2018-12-13 15:59:18
Modify Date: 2025-08-21 17:33:08
1-Boc-azetidine-3-yl-methanol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-yl-methanol is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]

Name	1-Boc-3-azetidinemethanol
Synonyms	1-Boc-Azetidine-3-yl-methanol tert-butyl 3-(hydroxymethyl)azetidine-1-carboxylate 3-(Hydroxymethyl)azetidine-1-carboxylate 1-(tert-Butoxycarbonyl)-3-azetidinemethanol 1-Boc-3-(hydroxymethyl)azetidine

Description	1-Boc-azetidine-3-yl-methanol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-yl-methanol is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Density	1.1±0.1 g/cm3
Boiling Point	270.3±13.0 °C at 760 mmHg
Melting Point	55 °C
Molecular Formula	C₉H₁₇NO₃
Molecular Weight	187.236
Flash Point	117.3±19.8 °C
Exact Mass	187.120850
PSA	49.77000
LogP	0.01
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.489
Water Solubility	Soluble in Dimethyl sulfoxide (DMSO).

142253-55-2

~98%

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Literature: EP1961750 A1, ; Page/Page column 90 ;

610791-05-4

~99%

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Literature: WO2013/83991 A1, ; Page/Page column 69-70 ;

72351-36-1

24424-99-5

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Literature: US2010/261701 A1, ; Page/Page column 145 ;

928038-44-2

24424-99-5

~74%

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Literature: Journal of Medicinal Chemistry, , vol. 51, # 4 p. 948 - 956

142253-55-2

543-27-1

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Literature: WO2005/28474 A2, ; Page/Page column 219 ; WO 2005/028474 A2

24424-99-5

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Literature: European Journal of Medicinal Chemistry, , vol. 34, # 5 p. 363 - 380

541-41-3

142253-55-2

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Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 20 p. 5581 - 5585

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%