Methylamino-PEG2-acid HCl

Modify Date: 2024-01-31 07:57:47

Methylamino-PEG2-acid HCl Structure
Methylamino-PEG2-acid HCl structure
Common Name Methylamino-PEG2-acid HCl
CAS Number 1807503-87-2 Molecular Weight 191.225
Density 1.1±0.1 g/cm3 Boiling Point 310.2±27.0 °C at 760 mmHg
Molecular Formula C8H17NO4 Melting Point N/A
MSDS N/A Flash Point 141.4±23.7 °C

 Use of Methylamino-PEG2-acid HCl


Methylamino-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Methylamino-PEG2-acid
Synonym More Synonyms

 Methylamino-PEG2-acid HCl Biological Activity

Description Methylamino-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 310.2±27.0 °C at 760 mmHg
Molecular Formula C8H17NO4
Molecular Weight 191.225
Flash Point 141.4±23.7 °C
Exact Mass 191.115753
LogP -0.90
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.453

 Synonyms

MFCD28155205
Propanoic acid, 3-[2-[2-(methylamino)ethoxy]ethoxy]-
3-{2-[2-(Methylamino)ethoxy]ethoxy}propanoic acid