Fmoc-N-amido-PEG2-alcohol

Modify Date: 2024-01-04 09:39:32

Fmoc-N-amido-PEG2-alcohol Structure
Fmoc-N-amido-PEG2-alcohol structure
Common Name Fmoc-N-amido-PEG2-alcohol
CAS Number 299430-87-8 Molecular Weight 327.37400
Density 1.221g/cm3 Boiling Point 547.8ºC at 760 mmHg
Molecular Formula C19H21NO4 Melting Point N/A
MSDS Chinese USA Flash Point 285.1ºC

 Use of Fmoc-N-amido-PEG2-alcohol


Fmoc-N-amido-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 9H-fluoren-9-ylmethyl N-[2-(2-hydroxyethoxy)ethyl]carbamate
Synonym More Synonyms

 Fmoc-N-amido-PEG2-alcohol Biological Activity

Description Fmoc-N-amido-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.221g/cm3
Boiling Point 547.8ºC at 760 mmHg
Molecular Formula C19H21NO4
Molecular Weight 327.37400
Flash Point 285.1ºC
Exact Mass 327.14700
PSA 67.79000
LogP 2.92490
Vapour Pressure 7.81E-13mmHg at 25°C
Index of Refraction 1.588
Storage condition 2-8°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

AmbotzFAL3010