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33755-53-2

33755-53-2 structure
33755-53-2 structure
  • Name: (+)-Biotin-ONP
  • Chemical Name: (4-nitrophenyl) 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoate
  • CAS Number: 33755-53-2
  • Molecular Formula: C16H19N3O5S
  • Molecular Weight: 365.404
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-17 19:12:41
  • Modify Date: 2025-08-25 12:03:12
  • (+)-Biotin-ONP is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Name (4-nitrophenyl) 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoate
Synonyms 1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, 4-nitrophenyl ester, (3aS,4S,6aR)-
Biotin-p-nitrophenyl ester
D-biotin 4-nitrophenyl ester
MFCD00005540
D-Biotin P-Nitrophenyl Ester
(+)-Biotin 4-nitrophenyl ester
Biotinyl-4-nitrophenyl ester
D-(+)-biotin 2-nitrophenyl ester
4-Nitrophenyl 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate
BNP,D-Biotin 4-nitrophenyl ester
4-Nitrophenyl (+)-biotinate
Description (+)-Biotin-ONP is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl-Chain

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
Density 1.3±0.1 g/cm3
Boiling Point 642.9±50.0 °C at 760 mmHg
Melting Point 163-165ºC
Molecular Formula C16H19N3O5S
Molecular Weight 365.404
Flash Point 342.6±30.1 °C
Exact Mass 365.104553
PSA 138.55000
LogP 1.89
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.584
Safety Phrases S22-S24/25
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title: CAS No. 33755-53-2 | Chemsrc address: https://www.chemsrc.com/en/baike/749964.html

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