142439-92-7

142439-92-7 structure

Name: NHS-SS-(+)-Biotin
Chemical Name: (2,5-dioxopyrrolidin-1-yl) 3-[[3-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethylamino]-3-oxopropyl]disulfanyl]propanoate
CAS Number: 142439-92-7
Molecular Formula: C₂₂H₃₃N₅O₇S₃
Molecular Weight: 575.72200
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-12-24 18:07:06
Modify Date: 2025-08-26 21:11:05
Biotin-bis-amido-SS-NHS is an Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.

Name	(2,5-dioxopyrrolidin-1-yl) 3-[[3-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethylamino]-3-oxopropyl]disulfanyl]propanoate
Synonyms	Succinimidyl 3-[3-[2-(biotinamido)ethyl]amino-3-oxopropyl]dithio]propionate NHS-SS-Biotin Biotin disulfide N-hydroxysuccinimide ester (2-[Biotinamido]ethylamido)-3,3 inverted exclamation marka-dithiodipropionic acid N-hydroxysuccinimide ester

Description	Biotin-bis-amido-SS-NHS is an Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl/ether
In Vitro	Biotin-bis-amido-SS-NHS is a long arm biotin containing disulfide bond, and the compound can be applied to biochemistry detection field, reduce the influence of steric effect, improve the sensitivity of detection[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Liyanping, et al. A kind of long arm biotin containing disulfide bond and preparation method thereof. Patent CN107383054A.

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H360D
Precautionary Statements	P201-P308 + P313
Hazard Codes	T: Toxic;
Risk Phrases	61
Safety Phrases	53-23-36/37/39-45
RIDADR	NONH for all modes of transport