PROTAC Linker

Total: 1884
Updated: 2019-06-28 15:55:20
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.

Anti-infection >
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ADC Cytotoxin ADC Linker Drug-Linker Conjugates for ADC PROTAC-linker Conjugate for PAC
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Neuronal Signaling >
5-HT Receptor AChE Adenosine Kinase Amyloid-β Beta-secretase CaMK CGRP Receptor COMT Dopamine Receptor Dopamine Transporter FAAH GABA Receptor GlyT iGluR Imidazoline Receptor mAChR Melatonin Receptor Monoamine Oxidase nAChR Neurokinin Receptor Opioid Receptor Serotonin Transporter γ-secretase
NF-κB >
NF-κB IKK Keap1-Nrf2 MALT1
PI3K/Akt/mTOR >
Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN
PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
Protein Tyrosine Kinase/RTK >
Ack1 ALK Bcr-Abl BMX Kinase Btk c-Fms c-Kit c-Met/HGFR Discoidin Domain Receptor DYRK EGFR Ephrin Receptor FAK FGFR FLT3 IGF-1R Insulin Receptor IRAK Itk PDGFR PKA Pyk2 ROS Src Syk TAM Receptor Trk Receptor VEGFR
Stem Cell/Wnt >
Casein Kinase ERK Gli GSK-3 Hedgehog Hippo (MST) JAK Notch Oct3/4 PKA Porcupine ROCK sFRP-1 Smo STAT TGF-beta/Smad Wnt YAP β-catenin γ-secretase
TGF-beta/Smad >
TGF-beta/Smad PKC ROCK TGF-β Receptor
Vitamin D Related >
VD/VDR
Others >
Androgen Receptor Aromatase Estrogen Receptor/ERR Progesterone Receptor Thyroid Hormone Receptor Others
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H-Glu-OtBu

H-Glu-OtBu is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Glu-OtBu is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2

  • CAS Number: 45120-30-7
  • MF: C9H17NO4
  • MW: 203.236
  • Catalog: ADC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 326.8±32.0 °C at 760 mmHg
  • Melting Point: 140ºC
  • Flash Point: 151.5±25.1 °C
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BnO-PEG1-CH2CO2tBu

BnO-PEG1-CH2CO2tBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1309451-06-6
  • MF: C15H22O4
  • MW: 266.33300
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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(S,R,S)-AHPC-PEG2-acid

(S,R,S)-AHPC-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2172820-09-4
  • MF: C30H42N4O8S
  • MW: 618.74
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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(4-Oxo-4H-quinazolin-3-yl)-acetic acid

(4-Oxo-4H-quinazolin-3-yl)-acetic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 14663-53-7
  • MF: C10H8N2O3
  • MW: 204.18200
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: 444.6ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: N/A
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Tos-PEG1-CH2-Boc

Tos-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1643957-24-7
  • MF: C15H22O6S
  • MW: 330.397
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 449.0±30.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 225.4±24.6 °C
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Benzyl-PEG5-acid

Benzyl-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2514948-41-3
  • MF: C18H28O7
  • MW: 356.41
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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TCO-PEG2-amine

TCO-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 2141981-87-3
  • MF: C15H28N2O4
  • MW: 300.39
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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TAMRA-Azide-PEG-Biotin

TAMRA-Azide-PEG-biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1797415-74-7
  • MF: C57H79N11O14S
  • MW: 1174.38
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG3-amido-C3-triethoxysilane

m-PEG3-amido-C3-triethoxysilane is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 2243566-45-0
  • MF: C17H37NO7Si
  • MW: 395.56
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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PC DBCO-PEG4-NHS ester

PC DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055025-02-8
  • MF: C47H55N5O16
  • MW: 945.96
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Fmoc-PEG6-NHS ester

Fmoc-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1818294-31-3
  • MF: C34H44N2O12
  • MW: 672.719
  • Catalog: PROTAC Linker
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Br-PEG3-C2-Boc

Br-PEG3-C2-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 782475-37-0
  • MF: C13H25BrO5
  • MW: 341.239
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 375.4±27.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 180.8±23.7 °C
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Carboxy-PEG4-phosphonic acid ethyl ester

Carboxy-PEG4-phosphonic acid ethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1964503-39-6
  • MF: C15H31O9P
  • MW: 386.38
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Hydroxy-PEG2-acid

Hydroxy-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1334286-77-9
  • MF: C7H14O5
  • MW: 178.18306
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Hydroxy-PEG4-methyl acetate

Hydroxy-PEG4-methyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 77303-64-1
  • MF: C11H22O7
  • MW: 266.28800
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-(acid-PEG3)-N-bis(PEG3-azide)

N-(acid-PEG3)-N-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2182602-17-9
  • MF: C25H49N7O11
  • MW: 623.70
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Propargyl-PEG5-PFP ester

Propargyl-PEG5-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2148295-92-3
  • MF: C20H23F5O7
  • MW: 470.38
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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TCO-OH

TCO-OH is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 85081-69-2
  • MF: C8H14O
  • MW: 126.19600
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Mal-amino-sulfo

Mal-amino-sulfo is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 158018-81-6
  • MF: C12H12N2O9S
  • MW: 360.29700
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Propargyl-PEG4-S-PEG4-propargyl

Propargyl-PEG4-S-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055041-17-1
  • MF: C22H38O8S
  • MW: 462.60
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG4-alpha-D- mannose

Azido-PEG4-alpha-D-mannose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1632372-86-1
  • MF: C14H27N3O9
  • MW: 381.38
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG3-S-PEG3-Boc

m-PEG3-S-PEG3-Boc is a PEG- and Alkyl/ether -based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055040-96-3
  • MF: C20H40O8S
  • MW: 440.59
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Bromo-PEG2-THP

Bromo-PEG2-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 152065-54-8
  • MF: C9H17BrO3
  • MW: 253.13
  • Catalog: PROTAC Linker
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 314.3±37.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 126.8±25.0 °C
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Benzyl-PEG5-Ots

Benzyl-PEG5-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 129086-10-8
  • MF: C24H34O8S
  • MW: 482.59
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Bis-aminooxy-PEG4

Bis-aminooxy-PEG4 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 98627-72-6
  • MF: C10H24N2O6
  • MW: 268.31
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG4-beta-D-glucose

Azido-PEG4-beta-D-glucose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1609083-15-9
  • MF: C14H27N3O9
  • MW: 381.38
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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2,3,5,6-Tetrafluorophenyl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14,17,20,23,26-octaoxa-2-azanonacosan-29-oate

TCO-PEG8-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2353410-06-5
  • MF: C34H51F4NO12
  • MW: 741.76
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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TCO-PEG8-amine

TCO-PEG8-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 2353409-92-2
  • MF: C27H52N2O10
  • MW: 564.71
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Hydroxy-PEG6-Boc

Hydroxy-PEG7-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 361189-64-2
  • MF: C19H38O9
  • MW: 410.50000
  • Catalog: PROTAC Linker
  • Density: 1.068 g/ml
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Hydroxy-PEG3-acid

Hydroxy-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 518044-49-0
  • MF: C9H18O6
  • MW: 266.288
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 420.7±40.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 155.5±20.8 °C
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