Hydroxy-PEG3-acid

Modify Date: 2024-01-12 09:16:00

Hydroxy-PEG3-acid Structure
Hydroxy-PEG3-acid structure
Common Name Hydroxy-PEG3-acid
CAS Number 518044-49-0 Molecular Weight 266.288
Density 1.2±0.1 g/cm3 Boiling Point 420.7±40.0 °C at 760 mmHg
Molecular Formula C9H18O6 Melting Point N/A
MSDS N/A Flash Point 155.5±20.8 °C

 Use of Hydroxy-PEG3-acid


Hydroxy-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name PEG4-acid
Synonym More Synonyms

 Hydroxy-PEG3-acid Biological Activity

Description Hydroxy-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 420.7±40.0 °C at 760 mmHg
Molecular Formula C9H18O6
Molecular Weight 266.288
Flash Point 155.5±20.8 °C
Exact Mass 266.136566
LogP -2.07
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.466

 Safety Information

Hazard Codes Xi

 Synonyms

MFCD22574805
1-Hydroxy-3,6,9,12-tetraoxapentadecan-15-oic acid
3,6,9,12-Tetraoxapentadecan-15-oic acid, 1-hydroxy-
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