Hydroxy-PEG3-(CH2)2-Boc

Modify Date: 2024-01-03 13:47:18

Hydroxy-PEG3-(CH2)2-Boc Structure
Hydroxy-PEG3-(CH2)2-Boc structure
Common Name Hydroxy-PEG3-(CH2)2-Boc
CAS Number 186020-66-6 Molecular Weight 278.34200
Density 1.057g/cm3 Boiling Point 365.8ºC at 760 mmHg
Molecular Formula C13H26O6 Melting Point N/A
MSDS Chinese USA Flash Point 125.2ºC

 Use of Hydroxy-PEG3-(CH2)2-Boc


Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196)[1].

 Names

Name tert-butyl 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]propanoate
Synonym More Synonyms

 Hydroxy-PEG3-(CH2)2-Boc Biological Activity

Description Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196)[1].
Related Catalog
Target

Non-cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References

[1]. Qingqi Chen,et al. The use of isocyanate linkers to make hydrolyzable active agent biopolymer conjugates. Patent WO2004008101A2.

 Chemical & Physical Properties

Density 1.057g/cm3
Boiling Point 365.8ºC at 760 mmHg
Molecular Formula C13H26O6
Molecular Weight 278.34200
Flash Point 125.2ºC
Exact Mass 278.17300
PSA 74.22000
LogP 0.76030
Vapour Pressure 7.78E-07mmHg at 25°C
Index of Refraction 1.45

 Safety Information

Personal Protective Equipment Eyeshields;Gloves
Hazard Codes Xi
RIDADR NONH for all modes of transport
HS Code 2918990090

 Synthetic Route

~94%

Hydroxy-PEG3-(CH2)2-Boc Structure

Hydroxy-PEG3-(C...

CAS#:186020-66-6

Literature: Wilbur, D. Scott; Pathare, Pradip M.; Hamlin, Donald K.; Wan, Feng Patent: US2006/228325 A1, 2006 ; Location in patent: Page/Page column 63 ;

 Customs

HS Code 2918990090
Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles1

More Articles

Angew. Chem. Int. Ed. Engl. 113 , 379, (2001)

 Synonyms

Hydroxy-PEG3-t-butyl ester
12-hydroxy-4,7,10-trioxadodecanoic acid tert-butyl ester
tert-Butyl triethylene glycol-O-propionate
tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate
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