Hydroxy-PEG3-NHS

Modify Date: 2024-01-10 14:03:59

Hydroxy-PEG3-NHS Structure
Hydroxy-PEG3-NHS structure
Common Name Hydroxy-PEG3-NHS
CAS Number 1807518-71-3 Molecular Weight 319.308
Density 1.3±0.1 g/cm3 Boiling Point 458.0±55.0 °C at 760 mmHg
Molecular Formula C13H21NO8 Melting Point N/A
MSDS N/A Flash Point 230.8±31.5 °C

 Use of Hydroxy-PEG3-NHS


Hydroxy-PEG3-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Hydroxy-PEG3-NHS
Synonym More Synonyms

 Hydroxy-PEG3-NHS Biological Activity

Description Hydroxy-PEG3-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 458.0±55.0 °C at 760 mmHg
Molecular Formula C13H21NO8
Molecular Weight 319.308
Flash Point 230.8±31.5 °C
Exact Mass 319.126709
LogP -3.23
Vapour Pressure 0.0±2.5 mmHg at 25°C
Index of Refraction 1.509

 Synonyms

2,5-Pyrrolidinedione, 1-[3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-1-oxopropoxy]-
1-[(3-{2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy}propanoyl)oxy]-2,5-pyrrolidinedione
MFCD26793742
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