Hydroxy-PEG3-NHS

Names

[ Name ]:
Hydroxy-PEG3-NHS

[Synonym ]:
2,5-Pyrrolidinedione, 1-[3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-1-oxopropoxy]-
1-[(3-{2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy}propanoyl)oxy]-2,5-pyrrolidinedione
MFCD26793742

Biological Activity

[Description]:

Hydroxy-PEG3-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
458.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₂₁NO₈

[ Molecular Weight ]:
319.308

[ Flash Point ]:
230.8±31.5 °C

[ Exact Mass ]:
319.126709

[ LogP ]:
-3.23

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.509

Related Compounds

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