Hydroxy-PEG3-CH2-Boc

Names

[ Name ]:
Hydroxy-PEG3-CH2-Boc

[Synonym ]:
2-Methyl-2-propanyl {2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}acetate
Acetic acid, 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester
MFCD27977510

Biological Activity

[Description]:

Hydroxy-PEG3-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
351.2±27.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₂₄O₆

[ Molecular Weight ]:
264.315

[ Flash Point ]:
121.9±17.2 °C

[ Exact Mass ]:
264.157288

[ LogP ]:
0.11

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.449

Hydroxy-PEG3-CH2-Boc

Names

Biological Activity

Chemical & Physical Properties

Related Compounds