Ald-CH2-PEG4-CH2CO2tBu

Names

[ Name ]:
Ald-CH2-PEG4-CH2CO2tBu

Biological Activity

[Description]:

Ald-CH2-PEG3-CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of SGK3 kinase PROTAC degrader[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₂₆O₇

[ Molecular Weight ]:
306.35

[ Storage condition ]:
2-8°C

Ald-CH2-PEG4-CH2CO2tBu

Names

Biological Activity

Chemical & Physical Properties

Related Compounds