133803-81-3

133803-81-3 structure

Name: Hydroxy-PEG2-(CH2)2-Boc
Chemical Name: tert-butyl 3-[2-(2-hydroxyethoxy)ethoxy]propanoate
CAS Number: 133803-81-3
Molecular Formula: C₁₁H₂₂O₅
Molecular Weight: 234.28900
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2016-11-21 00:16:47
Modify Date: 2025-08-26 14:59:02
Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196)[1].

Name	tert-butyl 3-[2-(2-hydroxyethoxy)ethoxy]propanoate
Synonyms	9-hydroxy-4,7-dioxanonanoic acid tert-butyl ester Propanoic acid,3-[2-(2-hydroxyethoxy)ethoxy]-,1,1-dimethylethyl ester tert-butyl 3-[di(ethylene glycol)]propanoate tert-butyl 3-(2-(2-hydroxyethoxy)ethoxy)propanoate Hydroxy-PEG2-t-butyl ester

Description	Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References	[1]. Qingqi Chen,et al. The use of isocyanate linkers to make hydrolyzable active agent biopolymer conjugates. Patent WO2004008101A2.

Precursor 2
1663-39-4 111-46-6
DownStream 0