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1807537-40-1

1807537-40-1 structure
1807537-40-1 structure
  • Name: Hydroxy-PEG3-PFP ester
  • Chemical Name: Hydroxy-PEG3-PFP ester
  • CAS Number: 1807537-40-1
  • Molecular Formula: C15H17F5O6
  • Molecular Weight: 388.284
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-28 16:38:30
  • Modify Date: 2024-01-14 00:05:10
  • Hydroxy-PEG3-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name Hydroxy-PEG3-PFP ester
Synonyms Propanoic acid, 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 2,3,4,5,6-pentafluorophenyl ester
MFCD26793756
Pentafluorophenyl 3-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}propanoate
Description Hydroxy-PEG3-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.4±0.1 g/cm3
Boiling Point 440.3±45.0 °C at 760 mmHg
Molecular Formula C15H17F5O6
Molecular Weight 388.284
Flash Point 220.1±28.7 °C
Exact Mass 388.094543
LogP 1.02
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.460