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1818294-31-3

1818294-31-3 structure
1818294-31-3 structure
  • Name: Fmoc-PEG6-NHS ester
  • Chemical Name: Fmoc-PEG6-NHS ester
  • CAS Number: 1818294-31-3
  • Molecular Formula: C34H44N2O12
  • Molecular Weight: 672.719
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-22 16:03:34
  • Modify Date: 2024-01-20 13:39:31
  • Fmoc-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name Fmoc-PEG6-NHS ester
Synonyms MFCD24539479
9H-Fluoren-9-ylmethyl {21-[(2,5-dioxo-1-pyrrolidinyl)oxy]-21-oxo-3,6,9,12,15,18-hexaoxahenicos-1-yl}carbamate
Carbamic acid, N-[21-[(2,5-dioxo-1-pyrrolidinyl)oxy]-21-oxo-3,6,9,12,15,18-hexaoxaheneicos-1-yl]-, 9H-fluoren-9-ylmethyl ester
Description Fmoc-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Density 1.3±0.1 g/cm3
Molecular Formula C34H44N2O12
Molecular Weight 672.719
Exact Mass 672.289429
LogP 0.06
Index of Refraction 1.575
Storage condition 2-8°C