1643957-24-7

1643957-24-7 structure

Name: Tos-PEG1-CH2-Boc
Chemical Name: Tos-PEG2-CH2CO2tBu
CAS Number: 1643957-24-7
Molecular Formula: C₁₅H₂₂O₆S
Molecular Weight: 330.397
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-25 02:10:12
Modify Date: 2025-08-25 10:23:09
Tos-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Tos-PEG2-CH2CO2tBu
Synonyms	Acetic acid, 2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]-, 1,1-dimethylethyl ester 2-Methyl-2-propanyl (2-{[(4-methylphenyl)sulfonyl]oxy}ethoxy)acetate MFCD28122953

Description	Tos-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.