Mal-PEG4-C2-NH2 TFA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Ms-PEG4-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
SNIPER(ER)-87 consists of an inhibitor of apoptosis protein (IAP) ligand LCL161 derivative that is conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen by a PEG linker, and efficiently degrades the ERα protein (IC50=0.097 μM). SNIPER(ER)-87 preferentially recruits XIAP to ERα in the cells, and XIAP is the primary E3 ubiquitin ligase responsible for the SNIPER(ER)-87-induced ERα degradation[1][2].
m-PEG12-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
VH032-NH-CO-CH2-NHBoc is a Boc-modified VH032 (HY-120217) that acts as a ligand for VHL to recruit von Hippel-Lindau (VHL) proteins. VH032-NH-CO-CH2-NHBoc will remove the Boc protection under acidic conditions, and connect with the target protein ligand through a linker to form a PROTAC molecule, which is a key intermediate for the synthesis of PROTAC based on VHL ligand.
Methylamino-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
N-(PEG1-OH)-N-Boc-PEG2-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Aminooxy-PEG3-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Boc-bipiperidine-ethynylbenzoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of ARD-61[1].
S-acetyl-PEG6 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Pomalidomide 4'-alkylC5-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a PEG linker used in PROTAC technology.
PROTAC Linker 32 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 32 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Benzyl-PEG4-Azido is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Boc-Aminooxy-PEG2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Hydroxy-PEG3-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Boc-N-Amido-PEG5-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
N-Benzyl-N-bis-PEG4 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
N-Boc-serinol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Azido-PEG6-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Fmoc-N-amido-PEG20-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Bromo-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Mal-amide-PEG2-oxyamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Aminooxy-PEG4-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTAC CBP/P300 Degrader-1 is a potent PROTAC CBP/P300 degrader. PROTAC CBP/P300 Degrader-1 potently inhibited cell viability of multiple cancer cell lines[1].
PROTAC GPX4 degrader-1 (DC-2) is a PROTAC-based GPX4 degrader, with a DC50 of 0.03 μM in HT1080 cells[1].
FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology. FKBP12 PROTAC RC32 contains conjugation of Rapamycin (HY-10219) and a ligand for an E3 ubiquitin ligase (Pomalidomide; HY-10984)[1].
N-PEG3-N'-(azide-PEG3)-Cy5 (chloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Biotin-PEG4-amino-t-Bu-DADPS-C3-alykne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Propargyl-PEG6-NH2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
N-(azide-PEG3)-N'-(Amine-C3-Amide-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].