Boc-bipiperidine-ethynylbenzoic acid

Modify Date: 2024-01-10 09:23:38

Boc-bipiperidine-ethynylbenzoic acid Structure
Boc-bipiperidine-ethynylbenzoic acid structure
 Common Name Boc-bipiperidine-ethynylbenzoic acid
CAS Number 2308497-81-4 Molecular Weight 412.52
Density N/A Boiling Point N/A
Molecular Formula C24H32N2O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Boc-bipiperidine-ethynylbenzoic acid


Boc-bipiperidine-ethynylbenzoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of ARD-61[1].

 Names

Name Boc-bipiperidine-ethynylbenzoic acid

 Boc-bipiperidine-ethynylbenzoic acid Biological Activity

Description Boc-bipiperidine-ethynylbenzoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of ARD-61[1].
Related Catalog
Target

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Lijie Zhao, et al. A highly potent PROTAC androgen receptor (AR) degrader ARD-61 effectively inhibits AR-positive breast cancer cell growth in vitro and tumor growth in vivo. Neoplasia. 2020 Oct;22(10):522-532.

 Chemical & Physical Properties

Molecular Formula C24H32N2O4
Molecular Weight 412.52
Storage condition 2-8°C
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