2308497-81-4

2308497-81-4 structure

Name: Boc-bipiperidine-ethynylbenzoic acid
Chemical Name: Boc-bipiperidine-ethynylbenzoic acid
CAS Number: 2308497-81-4
Molecular Formula: C₂₄H₃₂N₂O₄
Molecular Weight: 412.52
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2022-01-12 11:52:42
Modify Date: 2024-01-10 09:23:38
Boc-bipiperidine-ethynylbenzoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of ARD-61[1].

Name	Boc-bipiperidine-ethynylbenzoic acid

Description	Boc-bipiperidine-ethynylbenzoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of ARD-61[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Lijie Zhao, et al. A highly potent PROTAC androgen receptor (AR) degrader ARD-61 effectively inhibits AR-positive breast cancer cell growth in vitro and tumor growth in vivo. Neoplasia. 2020 Oct;22(10):522-532.