FKBP12 PROTAC RC32
Modify Date: 2025-08-26 19:34:31
FKBP12 PROTAC RC32 structure
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Common Name | FKBP12 PROTAC RC32 | ||
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| CAS Number | 2375555-66-9 | Molecular Weight | 1426.69 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C75H107N7O20 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of FKBP12 PROTAC RC32FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology. FKBP12 PROTAC RC32 contains conjugation of Rapamycin (HY-10219) and a ligand for an E3 ubiquitin ligase (Pomalidomide; HY-10984)[1]. |
| Name | FKBP12 PROTAC RC32 |
|---|
| Description | FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology. FKBP12 PROTAC RC32 contains conjugation of Rapamycin (HY-10219) and a ligand for an E3 ubiquitin ligase (Pomalidomide; HY-10984)[1]. |
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| Related Catalog | |
| Target |
Cereblon |
| In Vitro | FKBP12 PROTAC RC32 (RC32; 0.1-1000 nM; for 12 hours) results in 50% protein degradation (DC50) of ~0.3 nM after only 12 hours of treatment[1]. Western Blot Analysis[1] Cell Line: Jurkat cells Concentration: 0.1, 1, 10, 100, 1000 nM Incubation Time: For 12 hours Result: Resulted in 50% protein degradation (DC50) of ~0.3 nM after only 12 h of treatment. |
| In Vivo | RC32 (RC32; i.p.; 30 mg/kg; twice a day; 1 day) degrades the FKBP12 protein in most of the organs of treated mice, except for the brain after only 1 day of treatment in mice[1]. RC32 (orally; 60 mg/kg; twice a day; for 1 day) significantly degrades FKBP12 in mice[1]. RC32 (i.p.; 8 mg/kg; twice a day; for 2 days) efficiently degrades the FKBP12 protein in most of the organs examined in Bama pigs (20 kg) [1]. RC32 (i.p.; 8 mg/kg; twice a day; for 3 days) efficiently degrades FKBP12 in the heart, liver, kidney, spleen, lung, and stomach of rhesus monkeys[1]. Animal Model: Male and female mice[1] Dosage: 30 mg/kg Administration: IP; twice a day; 1 day Result: Degraded the FKBP12 protein in most of the organs of treated mice after only 1 day of treatment. |
| References |
| Molecular Formula | C75H107N7O20 |
|---|---|
| Molecular Weight | 1426.69 |
| InChIKey | XCSUEITWRRFFMN-LPIXFUNRSA-N |
| SMILES | COC1CC2CCC(C)C(O)(O2)C(=O)C(=O)N2CCCCC2C(=O)OC(C(C)CC2CCC(OCCOCc3cn(CCOCCOCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)nn3)C(OC)C2)CC(=O)C(C)C=C(C)C(O)C(OC)C(=O)C(C)CC(C)C=CC=CC=C1C |
| Storage condition | -20°C |