m-PEGn-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
t-Boc-Aminooxy-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Azido-PEG3-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
E3 ligase Ligand 9 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 9 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
PROTAC HDAC6 degrader (Compound A6) is a potent and selective PROTAC HDAC6 degrader with a DC50 of 3.5 nM. PROTAC HDAC6 degrader shows promising antiproliferative activity via inducing apoptosis in myeloid leukemia cell lines[1].
AZ'6421 acts as Protcolysis Targeting Chimera (PROTAC) to selectively degrade estrogen receptor alpha. AZ'6421 has a potent anti-tumour effect to inhibit the uncontrolled cellular proliferation which arises from malignant disease. AZ'6421 can be used for the research of cancer such as breast cancer[1].
OPSS-PEG8-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Hydroxy-PEG4-C2-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Pom-8PEG, an E3 ligase ligand-linker conjugate, incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and an 8-unit PEG linker. Pom-8PEG can be used in the synthesis of PROTAC, such as IDO1 PROTAC degrader[1].
Ms-PEG12-m is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
N-(m-PEG4)-N'-(Biotin-PEG2-amido-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
ICG-Sulfo-OSu sodium is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
(S,R,S)-AHPC-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Tos-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
TCO-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Hydroxy-PEG4-methyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
TCO-OH is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Target Protein-binding moiety 8 is a compound binding to BCR-ABL, and used for inhibiting BCR-ABL activity.
TCO-PEG8-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Hydroxy-PEG7-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
cIAP1 Ligand-Linker Conjugates 16 is an E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACs.
Methyl acetate-PEG1-methyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Sulfo DBCO-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker and thalidomide, a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s > 100 μM)[1].
3-tert-Butyl-4-methoxyphenol is a PROTAC linker, belongs to alkyl/ether class, with insecticidal activity. 3-tert-Butyl-4-methoxyphenol also induced increased activities of glutathione (GSH) S-transferase and epoxide hydrolase in the liver and forestomach tissues of A/HeJ mice, regulating the carcinogen metabolism system[1][2].
Biotin-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
m-PEG4-NH-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Thalidomide 4'-ether-alkylC2-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
TCO-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].