54665-51-9

54665-51-9 structure

Name: Methyl acetate-PEG1-methyl acetate
Chemical Name: methyl 2-[2-(2-methoxy-2-oxoethoxy)ethoxy]acetate
CAS Number: 54665-51-9
Molecular Formula: C₈H₁₄O₆
Molecular Weight: 206.19300
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-05-01 04:26:25
Modify Date: 2024-01-07 20:42:06
Methyl acetate-PEG1-methyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	methyl 2-[2-(2-methoxy-2-oxoethoxy)ethoxy]acetate
Synonyms	dimethyl 3,6-dioxaoctane-1,8-dioate triglycolic acid dimethyl ester methyl 2-{2-[(methoxycarbonyl)methoxy]ethoxy}acetate ethane-1,2-diyldioxy-bis-acetic acid dimethyl ester Acetic acid,2,2'-[1,2-ethanediylbis(oxy)]bis-,dimethyl ester 3,6-dioxaoctanedioic acid dimethylester

Description	Methyl acetate-PEG1-methyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562