Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 3,6-Dioxoctanedioic acid bis-methyl ester
Price: Check
Purity: 95.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Methyl acetate-PEG1-methyl acetate
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

54665-51-9

54665-51-9 structure

54665-51-9 structure

Name: Methyl acetate-PEG1-methyl acetate
Chemical Name: methyl 2-[2-(2-methoxy-2-oxoethoxy)ethoxy]acetate
CAS Number: 54665-51-9
Molecular Formula: C₈H₁₄O₆
Molecular Weight: 206.19300
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-05-01 04:26:25
Modify Date: 2025-08-27 11:48:51
Methyl acetate-PEG1-methyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	methyl 2-[2-(2-methoxy-2-oxoethoxy)ethoxy]acetate
Synonyms	dimethyl 3,6-dioxaoctane-1,8-dioate triglycolic acid dimethyl ester methyl 2-{2-[(methoxycarbonyl)methoxy]ethoxy}acetate ethane-1,2-diyldioxy-bis-acetic acid dimethyl ester Acetic acid,2,2'-[1,2-ethanediylbis(oxy)]bis-,dimethyl ester 3,6-dioxaoctanedioic acid dimethylester

Description	Methyl acetate-PEG1-methyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula	C₈H₁₄O₆
Molecular Weight	206.19300
Exact Mass	206.07900
PSA	71.06000

186581-53-3 structure

186581-53-3

112-60-7 structure

112-60-7

~%

7040-23-5 structure

7040-23-5

54322-34-8 structure

54322-34-8

Detail

Literature: Kaulen, Johannes; Schaefer, Hans-J. Tetrahedron, 1982 , vol. 38, # 22 p. 3299 - 3308

Precursor 2
186581-53-3 112-60-7
DownStream 7
31249-95-3 136809-46-6 23978-55-4 69930-74-1
60350-18-7 62283-87-8 62283-88-9

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