Methyl acetate-PEG1-methyl acetate

Modify Date: 2024-01-07 20:42:06

Methyl acetate-PEG1-methyl acetate Structure
Methyl acetate-PEG1-methyl acetate structure
Common Name Methyl acetate-PEG1-methyl acetate
CAS Number 54665-51-9 Molecular Weight 206.19300
Density N/A Boiling Point N/A
Molecular Formula C8H14O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Methyl acetate-PEG1-methyl acetate


Methyl acetate-PEG1-methyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name methyl 2-[2-(2-methoxy-2-oxoethoxy)ethoxy]acetate
Synonym More Synonyms

 Methyl acetate-PEG1-methyl acetate Biological Activity

Description Methyl acetate-PEG1-methyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C8H14O6
Molecular Weight 206.19300
Exact Mass 206.07900
PSA 71.06000

 Synonyms

dimethyl 3,6-dioxaoctane-1,8-dioate
triglycolic acid dimethyl ester
methyl 2-{2-[(methoxycarbonyl)methoxy]ethoxy}acetate
ethane-1,2-diyldioxy-bis-acetic acid dimethyl ester
Acetic acid,2,2'-[1,2-ethanediylbis(oxy)]bis-,dimethyl ester
3,6-dioxaoctanedioic acid dimethylester