Methyl acetate-PEG1-methyl acetate

Names

[ Name ]:
Methyl acetate-PEG1-methyl acetate

[Synonym ]:
dimethyl 3,6-dioxaoctane-1,8-dioate
triglycolic acid dimethyl ester
methyl 2-{2-[(methoxycarbonyl)methoxy]ethoxy}acetate
ethane-1,2-diyldioxy-bis-acetic acid dimethyl ester
Acetic acid,2,2'-[1,2-ethanediylbis(oxy)]bis-,dimethyl ester
3,6-dioxaoctanedioic acid dimethylester

Biological Activity

[Description]:

Methyl acetate-PEG1-methyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₈H₁₄O₆

[ Molecular Weight ]:
206.19300

[ Exact Mass ]:
206.07900

[ PSA ]:
71.06000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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