PROTAC IRAK4 degrader-5 is a PROTAC-based IRAK4 degrader extracted from patent US20190192668A1, compound I-171[1].
(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-Me-C10-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC ligand, it can be used in PROTAC technology[1].
Tos-PEG9 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Mal-amido-PEG4-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Azido-PEG4-4-nitrophenyl carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Propargyl-PEG8-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively[1].
m-PEG12-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG12-OH is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Propargyl-PEG7-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
m-PEG10-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
TLR4-IN-C34-C2-COO is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis[1].
Thalidomide-amido-PEG2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Propargyl-PEG1-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
N'-Boc-N-(Gly-Oleoyl)-Lys is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
4-Boc-amino-22-dimethylbutyric acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Azetidin-3-ol hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azetidin-3-ol hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthes PROTAC.
Boc-NH-PEG7-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Biotin-PEG7-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
Pomalidomide-amido-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker. Pomalidomide-amido-C1-Br can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1 (HY-111758). PROTAC B-Raf degrader 1 has anti-cancer activity[1].
Biotin-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
α-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Fluorescein-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Hydroxy-PEG1-(CH2)2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
THP-PEG8-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
HO-PEG24-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
CRBN ligand-9 (Compound 4d) is a CRBN ligand (Ki: 8.9 μM). CRBN ligand-9 can be used for synthesis of PROTACs[1][2].
Bromoacetamido-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
AT6 is a PROTAC AT1 analogue, which is a highly selective bromodomain (Brd4) degrader.
Thalidomide-amido-PEG2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
t-Boc-Aminooxy-PEG7-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].