55003-81-1

55003-81-1 structure

Name: 2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione
Chemical Name: 2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindole-1,3-dione
CAS Number: 55003-81-1
Molecular Formula: C₁₃H₉N₃O₆
Molecular Weight: 303.23
Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
Create Date: 2017-04-13 04:05:22
Modify Date: 2024-01-10 14:24:42
CRBN ligand-9 (Compound 4d) is a CRBN ligand (Ki: 8.9 μM). CRBN ligand-9 can be used for synthesis of PROTACs[1][2].

Name	2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindole-1,3-dione
Synonyms	4-nitrothalidomide 2-(2,6-dioxo-3-piperidinyl)-5-nitro-1H-isoindole-1,3(2H)-dione 2-(2,6-dioxo-piperidin-3-yl)-5-nitro-isoindole-1,3-dione 1H-Isoindole-1,3(2H)-dione,2-(2,6-dioxo-3-piperidinyl)-5-nitro 2-(4'-Nitro-phthalimido)-glutarimid 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline N-(2,6-dioxopiperidin-3-yl)-4-nitrophthalimide

Description	CRBN ligand-9 (Compound 4d) is a CRBN ligand (Ki: 8.9 μM). CRBN ligand-9 can be used for synthesis of PROTACs[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
References	[1]. Heim C,et al. De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives. J Med Chem. 2019 Jul 25;62(14):6615-6629. [2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Molecular Formula	C₁₃H₉N₃O₆
Molecular Weight	303.23
Exact Mass	303.04900
PSA	132.86000
LogP	0.73300
Storage condition	2-8℃

5466-84-2

24666-56-6

~53%

55003-81-1

Literature: Celgene Corporation Patent: US6335/349 B1, 2002 ; Location in patent: Example 2 ; Title/Abstract Full Text Show Details Celgene Corporation Patent: US6335349 B1, 2002 ; Location in patent: Example 2 ;

2650-64-8

55003-81-1

Literature: Muller, George W.; Chen, Roger; Huang, Shaei-Yun; Corral, Laura G.; Wong, Lu Min; Patterson, Rebecca T.; Chen, Yuxi; Kaplan, Gilla; Stirling, David I. Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 11 p. 1625 - 1630

24666-55-5

55003-81-1

5466-84-2

2353-44-8

55003-81-1

Literature: Contino-Pepin, Christiane; Parat, Audrey; Perino, Sandrine; Lenoir, Christine; Vidal, Michel; Galons, Herve; Karlik, Stephen; Pucci, Bernard Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 878 - 881

Precursor 5
5466-84-2 24666-56-6 2650-64-8 24666-55-5
2353-44-8
DownStream 1
191732-76-0

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