40846-94-4
40846-94-4 structure
- Name: α-Lipoic acid-NHS
- Chemical Name: (2,5-dioxopyrrolidin-1-yl) 5-(dithiolan-3-yl)pentanoate
- CAS Number: 40846-94-4
- Molecular Formula: C12H17NO4S2
- Molecular Weight: 303.39800
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2016-02-22 09:03:40
- Modify Date: 2024-01-11 12:04:56
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α-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | (2,5-dioxopyrrolidin-1-yl) 5-(dithiolan-3-yl)pentanoate |
|---|---|
| Synonyms |
2,5-Pyrrolidinedione,1-[[5-(1,2-dithiolan-3-yl)-1-oxopentyl]oxy]
1-(5-[1,2]dithiolan-3-ylpentanoyloxy)pyrrolidine-2,5-dione 1-{[5-(1,2-dithiolan-3-yl)pentanoyl]oxy}-2,5-pyrrolidinedione |
| Description | α-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Melting Point | 93.0-97.0°C |
|---|---|
| Molecular Formula | C12H17NO4S2 |
| Molecular Weight | 303.39800 |
| Exact Mass | 303.06000 |
| PSA | 114.28000 |
| LogP | 2.24560 |
| Storage condition | -20°C |
| Precursor 3 | |
|---|---|
| DownStream 2 | |
