Fluorescein-PEG6- NHS ester

Modify Date: 2024-01-11 13:11:00

Fluorescein-PEG6- NHS ester Structure
Fluorescein-PEG6- NHS ester structure
Common Name Fluorescein-PEG6- NHS ester
CAS Number 1818294-35-7 Molecular Weight 839.861
Density 1.5±0.1 g/cm3 Boiling Point 976.2±75.0 °C at 760 mmHg
Molecular Formula C40H45N3O15S Melting Point N/A
MSDS N/A Flash Point 544.2±37.1 °C

 Use of Fluorescein-PEG6- NHS ester


Fluorescein-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Fluorescein-PEG6-NHS ester
Synonym More Synonyms

 Fluorescein-PEG6- NHS ester Biological Activity

Description Fluorescein-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 976.2±75.0 °C at 760 mmHg
Molecular Formula C40H45N3O15S
Molecular Weight 839.861
Flash Point 544.2±37.1 °C
Exact Mass 839.257141
LogP -1.08
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.649

 Synonyms

5-[({21-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-21-oxo-3,6,9,12,15,18-hexaoxahenicos-1-yl}carbamothioyl)amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
Benzoic acid, 5-[[23-[(2,5-dioxo-1-pyrrolidinyl)oxy]-23-oxo-1-thioxo-5,8,11,14,17,20-hexaoxa-2-azatricos-1-yl]amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-
MFCD23726632
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