SPDP-PEG6-NHS ester

Modify Date: 2025-08-27 08:23:02

SPDP-PEG6-NHS ester Structure
SPDP-PEG6-NHS ester structure
Common Name SPDP-PEG6-NHS ester
CAS Number 1818294-32-4 Molecular Weight 647.758
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C27H41N3O11S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SPDP-PEG6-NHS ester


SPDP-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name SPDP-PEG6-NHS ester
Synonym More Synonyms

 SPDP-PEG6-NHS ester Biological Activity

Description SPDP-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Molecular Formula C27H41N3O11S2
Molecular Weight 647.758
Exact Mass 647.218262
LogP -1.60
Index of Refraction 1.565

 Synonyms

MFCD24539467
N-{21-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-21-oxo-3,6,9,12,15,18-hexaoxahenicos-1-yl}-3-(2-pyridinyldisulfanyl)propanamide
Propanamide, N-[21-[(2,5-dioxo-1-pyrrolidinyl)oxy]-21-oxo-3,6,9,12,15,18-hexaoxaheneicos-1-yl]-3-(2-pyridinyldithio)-
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