Bis-PEG9-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG9-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Bromoacetamido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Azido-PEG3-amide-C3-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Propargyl-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Sulfo DBCO-PEG4-Maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 (WDR5) (extracted from patent WO2019246570A1)[1].
m-PEG3-Sulfone-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Ms-PEG4-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Bis-propargyl-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG4 is used for the synthesis of demethylvancomycin dimers[1][2].
Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis
Bis-aminooxy-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
HEMTAC CDK4/6 degrader 1 is a PROTAC connected by ligands for HSP90 and CDK4/6 with a Kd value of 35.7 μM. HEMTAC CDK4/6 degrader 1 induces CDK4/6 degradation in B16F10 melanoma cells. HEMTAC CDK4/6 degrader 1 arrests cell cycle at G0/G1 phase and induces apoptosis. HEMTAC CDK4/6 degrader 1 can be used in research of cancer[1].
3-Maleimidopropionic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
SCO-PEG3-COOH is a PROTAC linker and belongs to the PEG class. SCO-PEG3-COOH contains SCO and COOH that can be covalently combined with amino groups respectively. SCO is often used to react with amino acid residues of proteins or peptides, particularly lysine.
TCO-PEG6-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
m-PEG3-S-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Diazo Biotin-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Thalidomide-Piperazine 5-fluoride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
t-Butyl acetate-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
m-PEG7-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
HS-PEG11-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Azido-PEG4-tetra-Ac-beta-D-glucose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Lenalidomide-5-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC[1]
DBCO-PEG1-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Methyltetrazine-amido-PEG5-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Azido-PEG6-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Methyltetrazine-PEG24-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Dimethylamino-PEG2-C2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
DSPE-PEG-Biotin (MW 1000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
PROTAC RIPK degrader-2 is a nonpeptidic PROTAC which potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation[1].