2226303-74-6

2226303-74-6 structure

Name: 2-(2,6-Dioxopiperidin-3-yl)-5-(prop-2-yn-1-yloxy)isoindoline-1,3-dione
Chemical Name: Thalidomide-5-propargyl
CAS Number: 2226303-74-6
Molecular Formula: C₁₆H₁₂N₂O₅
Molecular Weight: 312.28
Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
Create Date: 2023-03-23 00:19:30
Modify Date: 2024-04-06 11:07:03
Thalidomide-5-propargyl is a propargyl-modified Thalidomide (HY-14658), that acts as a Cereblon ligand to recruit CRBN proteins. Thalidomide-5-propargyl use alkynyl group at the end to be directly used in the synthesis of triazoles in the synthesis of PROTAC molecules, and is a key intermediate in the synthesis of PROTAC molecules based on CRBN design[1].

Name	Thalidomide-5-propargyl
Synonyms	1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)- 2-(2,6-dioxopiperidin-3-yl)-5-(prop-2-yn-1-yloxy)isoindoline-1,3-dione

Description	Thalidomide-5-propargyl is a propargyl-modified Thalidomide (HY-14658), that acts as a Cereblon ligand to recruit CRBN proteins. Thalidomide-5-propargyl use alkynyl group at the end to be directly used in the synthesis of triazoles in the synthesis of PROTAC molecules, and is a key intermediate in the synthesis of PROTAC molecules based on CRBN design[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	Cereblon[1]
References	[1]. Crew, et al. Preparation of tau-protein targeting bifunctional compounds (PROTACS) as E3 ubiquitin ligase binding useful in treatment and prevention of diseases. United States, US20180125821 A1. 2018-05-10.