2280998-74-3

2280998-74-3 structure

Name: m-PEG11-acid
Chemical Name: m-PEG11-acid
CAS Number: 2280998-74-3
Molecular Formula: C₂₄H₄₈O₁₃
Molecular Weight: 544.63
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2020-04-05 18:49:55
Modify Date: 2024-01-03 13:00:09
m-PEG11-acid is a non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG11-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

Name	m-PEG11-acid

Description	m-PEG11-acid is a non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG11-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Wilfried Braje et al. Macrocyclic mcl-1 inhibitors and methods of use. WO2019035927A1. [2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.