Lenalidomide-OH

Modify Date: 2024-01-06 15:28:21

Lenalidomide-OH structure	Common Name	Lenalidomide-OH
	CAS Number	1416990-08-3	Molecular Weight	260.25
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₃H₁₂N₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Lenalidomide-OH

Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620 (HY-133137)[1].

Name	Lenalidomide-OH
Synonym	More Synonyms

Description	Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620 (HY-133137)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	Cereblon
In Vitro	Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
References	[1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.

Molecular Formula	C₁₃H₁₂N₂O₄
Molecular Weight	260.25

Hazard Codes	Xi

MFCD31794971

Lenalidomide-OH

Use of Lenalidomide-OH

Names

Lenalidomide-OH Biological Activity

Chemical & Physical Properties

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