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929-75-9

929-75-9 structure
929-75-9 structure
  • Name: Amino-PEG3-C2-Amine
  • Chemical Name: 3,6,9-Trioxaundecane-1,11-Diamine
  • CAS Number: 929-75-9
  • Molecular Formula: C8H20N2O3
  • Molecular Weight: 192.256
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-12-24 01:48:07
  • Modify Date: 2024-01-05 18:34:48
  • Amino-PEG3-C2-Amine is a PEG-based (3 units) PROTAC linker can be used in the synthesis of PROTACs.

Name 3,6,9-Trioxaundecane-1,11-Diamine
Synonyms EINECS 213-206-2
2,2'-[oxybis(ethane-2,1-diyloxy)]diethanamine
Ethanamine, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-
2,2'-[Oxybis(ethylenoxy)]diethylamine
2,2'-[Oxybis(2,1-ethanediyloxy)]diethanamine
MFCD00628164
3,6,9-trioxaundecamethylenediamine
Description Amino-PEG3-C2-Amine is a PEG-based (3 units) PROTAC linker can be used in the synthesis of PROTACs.
Related Catalog
In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

Density 1.0±0.1 g/cm3
Boiling Point 291.1±25.0 °C at 760 mmHg
Molecular Formula C8H20N2O3
Molecular Weight 192.256
Flash Point 131.8±16.8 °C
Exact Mass 192.147400
PSA 79.73000
LogP -1.94
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.462
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H315-H318-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R37/38;R41
Safety Phrases S26-S39
RIDADR NONH for all modes of transport
HS Code 2922199090

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Literature: EVONIK DEGUSSA GmbH; Klasovsky, Florian; Tacke, Thomas; Pfeffer, Jan Christoph; Haas, Thomas; Beller, Matthias; Martin, Andreas; Deutsch, Jens; Koeckritz, Angela; Imm, Sebastian; Haberland, Juergen Patent: US2013/331580 A1, 2013 ; Location in patent: Paragraph 0063 ;

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Literature: Gunzenhauser; Biala; Strazewski Nucleosides and Nucleotides, 1999 , vol. 18, # 6-7 p. 1223 - 1224

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Literature: Lill, Andreas; Scholich, Klaus; Stark, Holger Tetrahedron Letters, 2013 , vol. 54, # 49 p. 6682 - 6686

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Literature: US4705886 A1, ;

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Literature: Journal of Organic Chemistry USSR (English Translation), , vol. 16, p. 1124 - 1129 Zhurnal Organicheskoi Khimii, , vol. 16, # 6 p. 1301 - 1307

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Literature: US2709178 , ;

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Literature: Synthetic Communications, , vol. 21, # 1 p. 79 - 84

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Literature: Journal of Organic Chemistry, , vol. 63, # 5 p. 1727 - 1729
HS Code 2922199090
Summary 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%