Amino-PEG3-C2-Amine

Modify Date: 2025-08-25 21:42:41

Amino-PEG3-C2-Amine Structure
Amino-PEG3-C2-Amine structure
Common Name Amino-PEG3-C2-Amine
CAS Number 929-75-9 Molecular Weight 192.256
Density 1.0±0.1 g/cm3 Boiling Point 291.1±25.0 °C at 760 mmHg
Molecular Formula C8H20N2O3 Melting Point N/A
MSDS Chinese USA Flash Point 131.8±16.8 °C
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger

 Use of Amino-PEG3-C2-Amine


Amino-PEG3-C2-Amine is a PEG-based (3 units) PROTAC linker can be used in the synthesis of PROTACs.

 Names

Name 3,6,9-Trioxaundecane-1,11-Diamine
Synonym More Synonyms

 Amino-PEG3-C2-Amine Biological Activity

Description Amino-PEG3-C2-Amine is a PEG-based (3 units) PROTAC linker can be used in the synthesis of PROTACs.
Related Catalog
In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 291.1±25.0 °C at 760 mmHg
Molecular Formula C8H20N2O3
Molecular Weight 192.256
Flash Point 131.8±16.8 °C
Exact Mass 192.147400
PSA 79.73000
LogP -1.94
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.462
InChIKey NIQFAJBKEHPUAM-UHFFFAOYSA-N
SMILES NCCOCCOCCOCCN

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H315-H318-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R37/38;R41
Safety Phrases S26-S39
RIDADR NONH for all modes of transport
HS Code 2922199090

 Synthetic Route

~97%

Amino-PEG3-C2-Amine Structure

Amino-PEG3-C2-Amine

CAS#:929-75-9

Literature: EVONIK DEGUSSA GmbH; Klasovsky, Florian; Tacke, Thomas; Pfeffer, Jan Christoph; Haas, Thomas; Beller, Matthias; Martin, Andreas; Deutsch, Jens; Koeckritz, Angela; Imm, Sebastian; Haberland, Juergen Patent: US2013/331580 A1, 2013 ; Location in patent: Paragraph 0063 ;

~93%

Amino-PEG3-C2-Amine Structure

Amino-PEG3-C2-Amine

CAS#:929-75-9

Literature: Gunzenhauser; Biala; Strazewski Nucleosides and Nucleotides, 1999 , vol. 18, # 6-7 p. 1223 - 1224

~77%

Amino-PEG3-C2-Amine Structure

Amino-PEG3-C2-Amine

CAS#:929-75-9

Literature: Lill, Andreas; Scholich, Klaus; Stark, Holger Tetrahedron Letters, 2013 , vol. 54, # 49 p. 6682 - 6686

~%

Amino-PEG3-C2-Amine Structure

Amino-PEG3-C2-Amine

CAS#:929-75-9

Literature: US4705886 A1, ;

~%

Amino-PEG3-C2-Amine Structure

Amino-PEG3-C2-Amine

CAS#:929-75-9

Literature: Journal of Organic Chemistry USSR (English Translation), , vol. 16, p. 1124 - 1129 Zhurnal Organicheskoi Khimii, , vol. 16, # 6 p. 1301 - 1307

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Amino-PEG3-C2-Amine Structure

Amino-PEG3-C2-Amine

CAS#:929-75-9

Literature: US2709178 , ;

~%

Amino-PEG3-C2-Amine Structure

Amino-PEG3-C2-Amine

CAS#:929-75-9

Literature: Synthetic Communications, , vol. 21, # 1 p. 79 - 84

~%

Amino-PEG3-C2-Amine Structure

Amino-PEG3-C2-Amine

CAS#:929-75-9

Literature: Journal of Organic Chemistry, , vol. 63, # 5 p. 1727 - 1729

 Customs

HS Code 2922199090
Summary 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles4

More Articles
Orthogonal, convergent syntheses of dendrimers based on melamine with one or two unique surface sites for manipulation.

J. Am. Chem. Soc. 123 , 8914 - 8922 , (2001)

An orthogonal, convergent route for the introduction of substoichiometric numbers of latent surface sites into dendrimers based on melamine is used to prepare targets that display one or two Boc-prote...

Non-natural glycosphingolipids and structurally simpler analogues bind HIV-1 recombinant Gp120.

Bioorg. Med. Chem. 10 , 625- 637, (2002)

Interactions of recombinant gp120 (rgp120) with non-natural glycosphingolipids (GSLs) and structurally simpler analogues have been studied using a competitive adhesion assay. Conjugates of cellobiosyl...

Recapitulation of in vivo-like paracrine signals of human mesenchymal stem cells for functional neuronal differentiation of human neural stem cells in a 3D microfluidic system.

Biomaterials 63 , 177-88, (2015)

Paracrine signals produced from stem cells influence tissue regeneration by inducing the differentiation of endogenous stem or progenitor cells. However, many recent studies that have investigated par...

 Synonyms

EINECS 213-206-2
2,2'-[oxybis(ethane-2,1-diyloxy)]diethanamine
Ethanamine, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-
2,2'-[Oxybis(ethylenoxy)]diethylamine
2,2'-[Oxybis(2,1-ethanediyloxy)]diethanamine
MFCD00628164
3,6,9-trioxaundecamethylenediamine
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