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4246-51-9

4246-51-9 structure
4246-51-9 structure
  • Name: 4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE
  • Chemical Name: 4,7,10-Trioxa-1,13-Tridecanediamine
  • CAS Number: 4246-51-9
  • Molecular Formula: C10H24N2O3
  • Molecular Weight: 220.309
  • Catalog: Chemical reagent Organic reagent Polyamine
  • Create Date: 2019-01-03 16:58:50
  • Modify Date: 2025-08-22 21:38:33
  • PROTAC Linker 24 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 24 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Name 4,7,10-Trioxa-1,13-Tridecanediamine
Synonyms 4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE
3-[2-[2-(3-aminopropoxy)ethoxy]ethoxy]propan-1-amine
3,3'-[OXYBIS(ETHANE-2,1-DIYLOXY)]DIPROPAN-1-AMINE
Diethylene Glycol Bis(3-aMinopropyl) Ether
EINECS 224-207-2
MFCD00059850
3,3'-[Oxybis(2,1-ethanediyloxy)]di(1-propanamine)
1-Propanamine, 3,3'-[oxybis(2,1-ethanediyloxy)]bis-
3,3'-((Oxybis(ethane-2,1-diyl))bis(oxy))bis(propan-1-amine)
Bis[2-(3-aminopropoxy)ethyl] Ether
Description PROTAC Linker 24 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 24 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Related Catalog
Target

Alkyl/ether

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
Density 1.0±0.1 g/cm3
Boiling Point 310.6±0.0 °C at 760 mmHg
Melting Point -32 °C
Molecular Formula C10H24N2O3
Molecular Weight 220.309
Flash Point 148.0±17.4 °C
Exact Mass 220.178696
PSA 79.73000
LogP -1.51
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.464

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ID6475000
CHEMICAL NAME :
Diethylene glycol, di(3-aminopropyl) ether
CAS REGISTRY NUMBER :
4246-51-9
BEILSTEIN REFERENCE NO. :
1760709
LAST UPDATED :
199712
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C10-H24-N2-O3
MOLECULAR WEIGHT :
220.36
WISWESSER LINE NOTATION :
Z3O2O2O3Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4290 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4290 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2500 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1067 No. of Facilities: 307 (estimated) No. of Industries: 10 No. of Occupations: 10 No. of Employees: 13486 (estimated) No. of Female Employees: 3955 (estimated)
Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H314
Precautionary Statements P280-P305 + P351 + P338-P310
Personal Protective Equipment Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes C: Corrosive;
Risk Phrases R34
Safety Phrases S26-S36/37/39-S45
RIDADR UN 2735 8/PG 3
WGK Germany 2
RTECS ID6475000
Packaging Group III
Hazard Class 8
HS Code 2922199090
10143-54-1 structure

10143-54-1

22397-31-5 structure

22397-31-5

~%

4246-51-9 structure

4246-51-9

112-33-4 structure

112-33-4

Literature: AIR PRODUCTS AND CHEMICALS, INC. Patent: EP1512675 A1, 2005 ; Location in patent: Page/Page column 4-5; 7 ;
10143-54-1 structure

10143-54-1

22397-31-5 structure

22397-31-5

~%

4246-51-9 structure

4246-51-9

112-33-4 structure

112-33-4

Detail
Literature: AIR PRODUCTS AND CHEMICALS, INC. Patent: EP1512675 A1, 2005 ; Location in patent: Page/Page column 3; 6 ;
22397-31-5 structure

22397-31-5

~%

4246-51-9 structure

4246-51-9

Literature: Chekulaeva,I.A. et al. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1967 , p. 1752 - 1754 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1967 , p. 1829 - 1832
929-75-9 structure

929-75-9

1073123-93-9 structure

1073123-93-9

~%

4246-51-9 structure

4246-51-9

1073123-92-8 structure

1073123-92-8

Literature: Saggiomo, Vittorio; Luening, Ulrich European Journal of Organic Chemistry, 2008 , # 25 p. 4329 - 4333
HS Code 2922199090
Summary 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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