4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE

Modify Date: 2024-01-02 20:50:24

4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE structure	Common Name	4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE
	CAS Number	4246-51-9	Molecular Weight	220.309
	Density	1.0±0.1 g/cm3	Boiling Point	310.6±0.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₂₄N₂O₃	Melting Point	-32 °C
	MSDS	Chinese USA	Flash Point	148.0±17.4 °C
	Symbol	GHS05	Signal Word	Danger

Use of 4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE

PROTAC Linker 24 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 24 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Name	4,7,10-Trioxa-1,13-Tridecanediamine
Synonym	More Synonyms

Description	PROTAC Linker 24 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 24 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl/ether
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Density	1.0±0.1 g/cm3
Boiling Point	310.6±0.0 °C at 760 mmHg
Melting Point	-32 °C
Molecular Formula	C₁₀H₂₄N₂O₃
Molecular Weight	220.309
Flash Point	148.0±17.4 °C
Exact Mass	220.178696
PSA	79.73000
LogP	-1.51
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.464

4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ID6475000

CHEMICAL NAME :: Diethylene glycol, di(3-aminopropyl) ether

CAS REGISTRY NUMBER :: 4246-51-9

BEILSTEIN REFERENCE NO. :: 1760709

LAST UPDATED :: 199712

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H24-N2-O3

MOLECULAR WEIGHT :: 220.36

WISWESSER LINE NOTATION :: Z3O2O2O3Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4290 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4290 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2500 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1067 No. of Facilities: 307 (estimated) No. of Industries: 10 No. of Occupations: 10 No. of Employees: 13486 (estimated) No. of Female Employees: 3955 (estimated)

Symbol	GHS05
Signal Word	Danger
Hazard Statements	H314
Precautionary Statements	P280-P305 + P351 + P338-P310
Personal Protective Equipment	Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	C: Corrosive;
Risk Phrases	R34
Safety Phrases	S26-S36/37/39-S45
RIDADR	UN 2735 8/PG 3
WGK Germany	2
RTECS	ID6475000
Packaging Group	III
Hazard Class	8
HS Code	2922199090

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Literature: AIR PRODUCTS AND CHEMICALS, INC. Patent: EP1512675 A1, 2005 ; Location in patent: Page/Page column 4-5; 7 ;

3-(2-(2-hydroxy...

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Detail

Literature: AIR PRODUCTS AND CHEMICALS, INC. Patent: EP1512675 A1, 2005 ; Location in patent: Page/Page column 3; 6 ;

3,3'-((OXYBIS(E...

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4,7,10-TRIOXA-1...

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Literature: Chekulaeva,I.A. et al. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1967 , p. 1752 - 1754 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1967 , p. 1829 - 1832

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Literature: Saggiomo, Vittorio; Luening, Ulrich European Journal of Organic Chemistry, 2008 , # 25 p. 4329 - 4333

Precursor 4
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HS Code	2922199090
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE

3-[2-[2-(3-aminopropoxy)ethoxy]ethoxy]propan-1-amine

3,3'-[OXYBIS(ETHANE-2,1-DIYLOXY)]DIPROPAN-1-AMINE

Diethylene Glycol Bis(3-aMinopropyl) Ether

EINECS 224-207-2

MFCD00059850

3,3'-[Oxybis(2,1-ethanediyloxy)]di(1-propanamine)

1-Propanamine, 3,3'-[oxybis(2,1-ethanediyloxy)]bis-

3,3'-((Oxybis(ethane-2,1-diyl))bis(oxy))bis(propan-1-amine)

Bis[2-(3-aminopropoxy)ethyl] Ether

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE
Price: ￥188.0/25ml
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

Chengdu Pukang Biotechnology Co., Ltd.
China
Product Name: 4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE
Price: ￥Inquiry/10kg
Purity: 95.0%
Stocking Period: Inquiry
Contact: Lihua Yang

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4,7,10-trioxa-1,13-tridecanediamine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 1-Propanamine,3,3'-[oxybis(2,1-ethanediyloxy)]bis-
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: ￥34/5g

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4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE

Use of 4,7,10-TRIOXA-1,13-TRIDECANEDIAMINE

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