PROTAC Linker

Total: 1884
Updated: 2019-06-28 15:55:20
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.

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PI3K/Akt/mTOR >
Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN
PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
Protein Tyrosine Kinase/RTK >
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HO-PEG17-OH

HO-PEG17-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 351342-04-6
  • MF: C34H70O18
  • MW: 766.91
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Propargyl-PEG3-bromide

Propargyl-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 203740-63-0
  • MF: C9H15BrO3
  • MW: 251.118
  • Catalog: PROTAC Linker
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 287.8±25.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 115.0±21.7 °C
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Fmoc-NH-PEG3-amide-CH2OCH2COOH

Fmoc-NH-PEG3-amide-CH2OCH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 489427-26-1
  • MF: C27H34N2O9
  • MW: 530.56700
  • Catalog: PROTAC Linker
  • Density: 1.256g/cm3
  • Boiling Point: 794.8ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 434.5ºC
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1-(4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenoxy)-3,6,9,12-tetraoxapentadecan-15-oic acid

Methyltetrazine-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1802907-91-0
  • MF: C20H28N4O7
  • MW: 436.459
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 647.6±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 345.5±34.3 °C
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Ac4GalNAl

Ac4GalNAl is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1673590-09-4
  • MF: C19H25NO10
  • MW: 427.40
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Propargyl-PEG2-NHS ester

Propargyl-PEG2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2512228-06-5
  • MF: C12H15NO6
  • MW: 269.25
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-Azido-PEG4-N-Boc-N-PEG3-Boc

N-Azido-PEG4-N-Boc-N-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2093152-85-1
  • MF: C28H54N4O11
  • MW: 622.75
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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BnO-PEG1-CH2COOH

BnO-PEG1-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 93206-09-8
  • MF: C11H14O4
  • MW: 210.22600
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Triethylene glycol monododecyl ether

Triethylene glycol monododecyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 3055-94-5
  • MF: C18H38O4
  • MW: 318.492
  • Catalog: PROTAC Linker
  • Density: 0.9±0.1 g/cm3
  • Boiling Point: 412.0±25.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 202.9±23.2 °C
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N-(Boc-PEG1)-N-bis(PEG2-propargyl)

N-(Boc-PEG1)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2100306-63-4
  • MF: C23H40N2O7
  • MW: 456.57
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Biotin-PEG3-C3-NH2

Biotin-PEG3-C3-NH2 is a PEG-based PROTAC linker, with NH2 functional group, that can be used in the synthesis of PROTACs[1].

  • CAS Number: 183896-00-6
  • MF: C20H38N4O5S
  • MW: 446.60
  • Catalog: PROTAC Linker
  • Density: 1.139±0.06 g/cm3(Predicted)
  • Boiling Point: 715.3±60.0 °C(Predicted)
  • Melting Point: N/A
  • Flash Point: N/A
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Nonylbenzene-PEG5-OH

Nonylbenzene-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 20636-48-0
  • MF: C25H44O6
  • MW: 440.61300
  • Catalog: PROTAC Linker
  • Density: 1.016g/cm3
  • Boiling Point: 541.2ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 281.1ºC
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Benzyl-PEG1-Ms

Benzyl-PEG1-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 58841-52-4
  • MF: C10H16O5S
  • MW: 248.29600
  • Catalog: PROTAC Linker
  • Density: 1.218g/cm3
  • Boiling Point: 375.438ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 180.858ºC
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H2n-peg14-oh

Amino-PEG14-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 34214-89-6
  • MF: C28H59NO14
  • MW: 633.77
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Methyltetrazine-PEG5-NHS ester

Methyltetrazine-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1802907-92-1
  • MF: C24H31N5O9
  • MW: 533.53
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG10-acid

Azido-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Biotin-PEG2-C4-alkyne

Biotin-PEG2-C4-alkyne is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 1011268-28-2
  • MF: C22H36N4O5S
  • MW: 468.610
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 799.8±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 437.5±32.9 °C
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Methyl azetidine-3-carboxylate hydrochloride

Methyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs<

  • CAS Number: 100202-39-9
  • MF: C5H10ClNO2
  • MW: 151.591
  • Catalog: ADC Linker
  • Density: N/A
  • Boiling Point: 190.9ºC at 760 mmHg
  • Melting Point: 93.0 to 97.0 °C
  • Flash Point: 69.3ºC
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Bromoacetamido-PEG4-C2-Boc

Bromoacetamido-PEG4-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 1807521-00-1
  • MF: C17H32BrNO7
  • MW: 442.342
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 539.3±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 280.0±30.1 °C
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Acid-apeg8-acid n-boc

N-Boc-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2093152-88-4
  • MF: C27H51NO14
  • MW: 613.69
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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BDP FL-PEG5-acid

BDP FL-PEG5-acid is a BDP FL acid linker containing a hydrophilic PEG spacer arm. BDP FL-PEG5-acid can be used in the synthesis of PROTACs. BDP FL is a green-fluorescent dye, and the hydrophilic PEG spacer arm increases water solubility and membrane permability.

  • CAS Number: 2093197-98-7
  • MF: C27H40BF2N3O8
  • MW: 583.43
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-Boc-piperazine

N-Boc-piperazine is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183)[1].

  • CAS Number: 57260-71-6
  • MF: C9H18N2O2
  • MW: 186.251
  • Catalog: PROTAC Linker
  • Density: 1.0±0.1 g/cm3
  • Boiling Point: 258.0±15.0 °C at 760 mmHg
  • Melting Point: 47-49ºC
  • Flash Point: 109.8±20.4 °C
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N,N'-bis-(azide-PEG3)-chlorocyclohexenyl Cy7

N,N'-bis-(azide-PEG3)-chlorocyclohexenyl Cy7 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2107273-84-5
  • MF: C46H62Cl2N8O6
  • MW: 893.94
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG6-C2-Boc

Azido-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 406213-76-1
  • MF: C19H37N3O8
  • MW: 435.512
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Gly-PEG3-endo-BCN

Gly-PEG3-endo-BCN is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2354291-37-3
  • MF: C23H39N3O6
  • MW: 453.57
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Hydroxy-PEG3-acrylate

Hydroxy-PEG3-acrylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 16695-45-7
  • MF: C9H16O5
  • MW: 204.22000
  • Catalog: PROTAC Linker
  • Density: 1.098g/cm3
  • Boiling Point: 302.4ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 113ºC
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Methyl-PEG4-acyl chloride

Methyl-PEG4-acyl chloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 62124-69-0
  • MF: C10H19ClO6
  • MW: 270.70700
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Mal-​C2-cyclohexylcarboxyl-hydrazide TFA

Mal-​C2-cyclohexylcarboxyl-hydrazide (TFA) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 359436-59-2
  • MF: C14H18F3N3O5
  • MW: 365.305
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Mal-amido-PEG3-acid

Mal-amido-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055353-75-6
  • MF: C16H24N2O8
  • MW: 372.37
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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(Fmoc-amino)-PEG12-C2-Carboxylic Acid

Fmoc-NH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1952360-91-6
  • MF: C42H65NO16
  • MW: 839.96
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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