Biotin-PEG3-C3-NH2

Modify Date: 2024-01-31 19:51:24

Biotin-PEG3-C3-NH2 structure	Common Name	Biotin-PEG3-C3-NH2
	CAS Number	183896-00-6	Molecular Weight	446.60
	Density	1.139±0.06 g/cm3(Predicted)	Boiling Point	715.3±60.0 °C(Predicted)
	Molecular Formula	C₂₀H₃₈N₄O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Biotin-PEG3-C3-NH2

Biotin-PEG3-C3-NH2 is a PEG-based PROTAC linker, with NH2 functional group, that can be used in the synthesis of PROTACs[1].

Name	N-(3-(2-(2-(3-Aminopropoxy)ethoxy)ethoxy)propyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
Synonym	More Synonyms

Description	Biotin-PEG3-C3-NH2 is a PEG-based PROTAC linker, with NH2 functional group, that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTAC linkers exert function for connecting the two different ligands that make up PROTACs, the two ligands are E3 ubiquitin ligase and the target protein, respectively[1]. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. PROTAC can significantly attenuate tumor progression in tumor xenografts[1]. Biotin-PEG3-C3-NH2 (compound 11) (0-2 mM; 3 h) combinded with protein G (compound 6) displays fluorescence under streptavidin probes, Biotin-PEG3-C3-NH2 is a powerful tool for the high-throughput analysis of protein-small molecule interaction and profiling enzyme activities in a microarrays constructed by surface derivatization method[3].

Density	1.139±0.06 g/cm3(Predicted)
Boiling Point	715.3±60.0 °C(Predicted)
Molecular Formula	C₂₀H₃₈N₄O₅S
Molecular Weight	446.60

MFCD28053681