PROTAC Linker

Total: 1884
Updated: 2019-06-28 15:55:20
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.

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PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
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endo-BCN-PEG3-NH2

endo-BCN-PEG3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1883512-27-3
  • MF: C19H32N2O5
  • MW: 368.47
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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NH2-PEG2-C2-Boc

NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

  • CAS Number: 756525-95-8
  • MF: C11H23NO4
  • MW: 233.305
  • Catalog: ADC Linker
  • Density: 1.0±0.1 g/cm3
  • Boiling Point: 313.7±22.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 103.3±18.7 °C
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Hydroxy-PEG2-CH2COOH

Hydroxy-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 51951-04-3
  • MF: C6H12O5
  • MW: 164.156
  • Catalog: PROTAC Linker
  • Density: 1.2±0.0 g/cm3
  • Boiling Point: 343.4±0.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 144.3±0.0 °C
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m-PEG7-NHS ester

m-PEG7-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 874208-92-1
  • MF: C20H35NO11
  • MW: 465.49200
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG12-NH-C2-acid

m-PEG12-NH-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1949843-39-3
  • MF: C28H57NO14
  • MW: 631.75
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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EGNHS

EGNHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 70539-42-3
  • MF: C18H20N2O12
  • MW: 456.35800
  • Catalog: PROTAC Linker
  • Density: 1.52g/cm3
  • Boiling Point: 603.4ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 318.7ºC
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m-PEG5-phosphonic acid

m-PEG5-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1807512-39-5
  • MF: C11H25O8P
  • MW: 316.29
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG1-azide

Azido-PEG1-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 24345-74-2
  • MF: C4H8N6O
  • MW: 156.14600
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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t-Boc-N-Amido-PEG3-propargyl

Boc-NH-PEG3-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1333880-60-6
  • MF: C14H25NO5
  • MW: 287.35
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Thiol-PEG3-acid

Thiol-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1347750-82-6
  • MF: C9H18O5S
  • MW: 238.301
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 377.5±37.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 182.1±26.5 °C
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THP-PEG10-THP

THP-PEG10-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 42749-29-1
  • MF: C30H58O13
  • MW: 626.77
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azide-PEG7-Tos

Azide-PEG7-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1418561-41-7
  • MF: C21H35N3O9S
  • MW: 505.58
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Methyl-PEG3-Ald

Methyl-PEG3-Ald is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 141981-62-6
  • MF: C9H18O5
  • MW: 206.24
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG8-C-Boc

Azido-PEG8-C-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1984776-39-7
  • MF: C22H43N3O10
  • MW: 509.59
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Mal-PEG5-C2-NH2 hydrochloride

Mal-PEG5-C2-NH2 hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2454216-21-6
  • MF: C16H29ClN2O7
  • MW: 396.86
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Benzyl-PEG10-alcohol

Benzyl-PEG10-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 908258-44-6
  • MF: C27H48O11
  • MW: 548.66300
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Benzyloxy carbonyl-PEG3-t-butyl ester

Benzyloxy carbonyl-PEG3-C2-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1835759-86-8
  • MF: C21H32O7
  • MW: 396.47
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-Boc-piperazine-C3-COOH

N-Boc-piperazine-C3-COOH is a PROTAC linker, which refers to the alkyl/ether composition. Boc-N-piperazine-C3-COOH can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183)[1].

  • CAS Number: 959053-53-3
  • MF: C14H24N2O5
  • MW: 300.35
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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t-Boc-aminooxy-PEG1-propargyl

Boc-aminooxy-PEG1-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1895922-72-1
  • MF: C10H17NO4
  • MW: 215.25
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Amino-PEG11-acid

Amino-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1616426-12-0
  • MF: C25H51NO13
  • MW: 573.67
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Acid-PEG3-mono-methyl ester

Acid-PEG3-mono-methyl ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1807505-26-5
  • MF: C11H20O7
  • MW: 264.272
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 396.7±32.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 145.9±18.6 °C
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Propargyl-PEG4-tetra-Ac-beta-D-galactose

Propargyl-PEG4-tetra-Ac-beta-D-galactose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1397682-61-9
  • MF: C25H38O14
  • MW: 562.559999999999
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Propargyl-PEG5-CH2CO2H

Propargyl-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1429934-37-1
  • MF: C13H22O7
  • MW: 290.31
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Tos-PEG3-CH2COOH

Tos-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1581248-63-6
  • MF: C15H22O8S
  • MW: 362.395
  • Catalog: PROTAC Linker
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 539.9±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 280.3±28.7 °C
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Benzyl-PEG4-MS

Benzyl-PEG4-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 477781-69-4
  • MF: C16H26O7S
  • MW: 362.438
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 497.1±40.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 254.5±27.3 °C
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Azido-PEG4-hydrazide HCl

Azido-PEG4-hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2170240-96-5
  • MF: C11H23N5O5
  • MW: 305.33
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG8-PFP ester

Azido-PEG8-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2055014-62-3
  • MF: C25H36F5N3O10
  • MW: 633.56
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Propynyl-PEG1-Ac

Propynyl-PEG1-Ac is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 944561-45-9
  • MF: C7H10O4
  • MW: 158.15
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Azido-PEG3-chloroacetamide

Azido-PEG3-chloroacetamide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 604766-23-6
  • MF: C10H19ClN4O4
  • MW: 294.74
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Di(N-succinimidyl)adipate

Di(N-succinimidyl)adipate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 59156-70-6
  • MF: C14H16N2O8
  • MW: 340.28500
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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