756525-95-8

756525-95-8 structure

Name: NH2-PEG2-C2-Boc
Chemical Name: tert-butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate
CAS Number: 756525-95-8
Molecular Formula: C₁₁H₂₃NO₄
Molecular Weight: 233.305
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2019-01-05 19:09:47
Modify Date: 2025-08-25 17:49:25
NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

Name	tert-butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate
Synonyms	2-Methyl-2-propanyl 3-[2-(2-aminoethoxy)ethoxy]propanoate Propanoic acid, 3-[2-(2-aminoethoxy)ethoxy]-, 1,1-dimethylethyl ester tert-butyl 3-[2-(2-aminoethoxy)ethoxy]propanoate tert-butyl 9-AMino-4,7-dioxanonanoate

Description	NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether Non-cleavable
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
References	[1]. Han X, et al. Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer. J Med Chem. 2019 Jan 24;62(2):941-964. [2]. Joshua D. Thomas, et al. Pyrrolobenzodiazepine antibody conjugates. WO2019126691A1.