70539-42-3
70539-42-3 structure
- Name: EGNHS
- Chemical Name: 4-O-(2,5-dioxopyrrolidin-1-yl) 1-O-[2-[4-(2,5-dioxopyrrolidin-1-yl)oxy-4-oxobutanoyl]oxyethyl] butanedioate
- CAS Number: 70539-42-3
- Molecular Formula: C18H20N2O12
- Molecular Weight: 456.35800
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2018-12-24 21:32:33
- Modify Date: 2025-08-24 19:54:47
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EGNHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | 4-O-(2,5-dioxopyrrolidin-1-yl) 1-O-[2-[4-(2,5-dioxopyrrolidin-1-yl)oxy-4-oxobutanoyl]oxyethyl] butanedioate |
|---|---|
| Synonyms |
EGS
MFCD00049057 Peg-SS EGBSS |
| Description | EGNHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.52g/cm3 |
|---|---|
| Boiling Point | 603.4ºC at 760 mmHg |
| Molecular Formula | C18H20N2O12 |
| Molecular Weight | 456.35800 |
| Flash Point | 318.7ºC |
| Exact Mass | 456.10200 |
| PSA | 179.96000 |
| Index of Refraction | 1.56 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |