24345-74-2

24345-74-2 structure

Name: Azido-PEG1-azide
Chemical Name: 1-azido-2-(2-azidoethoxy)ethane
CAS Number: 24345-74-2
Molecular Formula: C₄H₈N₆O
Molecular Weight: 156.14600
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2017-01-20 04:04:04
Modify Date: 2024-01-15 08:19:55
Azido-PEG1-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1-azido-2-(2-azidoethoxy)ethane
Synonyms	bisethyletherazide 1-azido-2 (2-azidoethoxy)-ethane 1-(2-azidoethoxy)-2-azidoethane Ether,bis(2-azidoethyl) (7CI,8CI) 1,1'-Oxybis(2-azidoethane) Ethane,1,1'-oxybis[2-azido 1,5-diazido-3-oxapentane bis-(2-azido-ethyl) ether

Description	Azido-PEG1-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Molecular Formula	C₄H₈N₆O
Molecular Weight	156.14600
Exact Mass	156.07600
PSA	108.73000
LogP	0.52912

HS Code	2929909090

5414-19-7

~95%

24345-74-2

Literature: Thomas, Jason R.; Liu, Xianjun; Hergenrother, Paul J. Journal of the American Chemical Society, 2005 , vol. 127, # 36 p. 12434 - 12435

111-44-4

~62%

24345-74-2

Literature: Vereshchagin, L. I.; Tikhonova, L. G.; Maksikova, A. V.; Serebryakova, E. S.; Proidakov, A. G.; Filippova, T. M. Journal of Organic Chemistry USSR (English Translation), 1980 , vol. 16, # 4 p. 641 - 648 Zhurnal Organicheskoi Khimii, 1980 , vol. 16, # 4 p. 730 - 738

34604-52-9

24345-74-2

Literature: WO2011/25790 A1, ; Page/Page column 50 ;

Precursor 3
5414-19-7 111-44-4 34604-52-9
DownStream 1
2752-17-2

HS Code	2929909090
Summary	2929909090 other compounds with other nitrogen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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