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5414-19-7

5414-19-7 structure
5414-19-7 structure
  • Name: Bis(2-bromoethyl) ether
  • Chemical Name: 2,2'-Dibromodiethyl ether
  • CAS Number: 5414-19-7
  • Molecular Formula: C4H8Br2O
  • Molecular Weight: 231.914
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-03 08:00:00
  • Modify Date: 2025-08-25 14:52:03
  • Bis2-bromoethyl ether is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 2,2'-Dibromodiethyl ether
Synonyms MFCD00039196
1-Bromo-2-(2-bromoethoxy)ethane
2-Bromoethyl ether
2,2-Dibromodiethyl Ether
Ethane, 2,2'-oxybis[1-bromo-
2,2'-Dibromodiethyl Ether
2,2'-Dibromoethylether
Ether, bis(2-bromoethyl)
Ether, bis(2-bromoethyl) (8CI)
Ethane, 1,1'-oxybis[2-bromo-
Bis(2-bromoethyl) ether
DI(2-BROMOETHYL)ETHER
EINECS 226-504-2
Description Bis2-bromoethyl ether is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl-Chain

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.8±0.1 g/cm3
Boiling Point 216.3±0.0 °C at 760 mmHg
Molecular Formula C4H8Br2O
Molecular Weight 231.914
Flash Point 85.0±0.0 °C
Exact Mass 229.894180
PSA 9.23000
LogP 1.87
Vapour Pressure 0.2±0.4 mmHg at 25°C
Index of Refraction 1.506
Storage condition 2-8°C
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H315-H318-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes T:Toxic;
Risk Phrases R61;R37/38;R41
Safety Phrases S53-S26-S36/37/39-S45
RIDADR 2810
WGK Germany 3
Packaging Group III
Hazard Class 6.1
HS Code 2909199090
HS Code 2909199090
Summary 2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%
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