Bis(2-bromoethyl) ether

Modify Date: 2024-01-03 00:04:00

Bis(2-bromoethyl) ether Structure
Bis(2-bromoethyl) ether structure
Common Name Bis(2-bromoethyl) ether
CAS Number 5414-19-7 Molecular Weight 231.914
Density 1.8±0.1 g/cm3 Boiling Point 216.3±0.0 °C at 760 mmHg
Molecular Formula C4H8Br2O Melting Point N/A
MSDS Chinese USA Flash Point 85.0±0.0 °C
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger

 Use of Bis(2-bromoethyl) ether


Bis2-bromoethyl ether is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2,2'-Dibromodiethyl ether
Synonym More Synonyms

 Bis(2-bromoethyl) ether Biological Activity

Description Bis2-bromoethyl ether is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl-Chain

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 216.3±0.0 °C at 760 mmHg
Molecular Formula C4H8Br2O
Molecular Weight 231.914
Flash Point 85.0±0.0 °C
Exact Mass 229.894180
PSA 9.23000
LogP 1.87
Vapour Pressure 0.2±0.4 mmHg at 25°C
Index of Refraction 1.506
Storage condition 2-8°C

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H315-H318-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes T:Toxic;
Risk Phrases R61;R37/38;R41
Safety Phrases S53-S26-S36/37/39-S45
RIDADR 2810
WGK Germany 3
Packaging Group III
Hazard Class 6.1
HS Code 2909199090

 Synthetic Route

 Customs

HS Code 2909199090
Summary 2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

 Articles5

More Articles
Asymmetric synthesis of functionalized diarylmethanols catalyzed by a new gamma-amino thiol.

J. Org. Chem. 71(2) , 833-5, (2006)

[reaction: see text] A mild asymmetric arylation of aromatic aldehydes catalyzed by gamma-amino thiol 5 gave the corresponding diarylmethanols with 95 to >99.5% ee.

J. Chem. Soc. Chem. Commun. , 1550, (1992)

J. Chem. Soc., Perkin Trans. II , 1213, (1989)

 Synonyms

MFCD00039196
1-Bromo-2-(2-bromoethoxy)ethane
2-Bromoethyl ether
2,2-Dibromodiethyl Ether
Ethane, 2,2'-oxybis[1-bromo-
2,2'-Dibromodiethyl Ether
2,2'-Dibromoethylether
Ether, bis(2-bromoethyl)
Ether, bis(2-bromoethyl) (8CI)
Ethane, 1,1'-oxybis[2-bromo-
Bis(2-bromoethyl) ether
DI(2-BROMOETHYL)ETHER
EINECS 226-504-2
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