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59156-70-6

59156-70-6 structure
59156-70-6 structure
  • Name: Di(N-succinimidyl)adipate
  • Chemical Name: bis(2,5-dioxopyrrolidin-1-yl) hexanedioate
  • CAS Number: 59156-70-6
  • Molecular Formula: C14H16N2O8
  • Molecular Weight: 340.28500
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2016-04-30 10:15:35
  • Modify Date: 2024-01-02 22:00:43
  • Di(N-succinimidyl)adipate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name bis(2,5-dioxopyrrolidin-1-yl) hexanedioate
Synonyms adipic acid di-N-hydroxysuccinimide ester
di-(N-hydroxysuccinimidyl) adipate ester
bis(N-hydroxysuccinimidyl) adipate
disuccinimidyl adipate
bis(N-hydroxysuccinimidyl) adipic acid diester
Di(N-succinimidyl) adipate
adipic acid bis(succinimidyl) ester
2,5-Pyrrolidinedione,1,1'-[(1,6-dioxo-1,6-hexanediyl)bis(oxy)]bis
Description Di(N-succinimidyl)adipate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl-Chain

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula C14H16N2O8
Molecular Weight 340.28500
Exact Mass 340.09100
PSA 127.36000
Precursor  2

DownStream  0